The prognosis for patients with metastatic melanoma remains very poor. Constitutive signal
transducer and activator of transcription 3 (STAT3) activation has been correlated to …

Background Melanoma is one of the most aggressive tumors with the remarkable
characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted …

Background Fyn has been documented to have oncogenic features in multiple tumors,
which might be a potential therapeutic target, however, few studies on the function role of …

Lymphomas are still difficult to treat even with modern therapies as, among others, multidrug
resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters …

Purpose: Melanoma is the most invasive and deadly form of skin cancer. Few agents are
available for treating advanced disease to enable long-term patient survival, which is driving …

Melanoma is a highly malignant neoplasm of melanocytes with considerable metastatic
potential and drug resistance, explaining the need for new candidates that inhibit tumor …

Aim: The increasing number of cancer cases has stimulated researchers to seek for novel
approaches. We have combined two bioactive moieties: a polyphenolic scaffold and an …

Previous studies have established the in vivo bioavailability and efficacious dosages of
phenylbutyl isoselenocyanate (ISC‐4), a selenium‐substituted isothiocyanate, against …

Organoselenium (OSe) agents hold promise for preventing cancer due to their potential
ability to fight cancer development and protect cells from oxidative damage. Herein, OSe …

The JAK2/STAT3 signaling pathway plays a critical role in tumorigenesis, and has been
suggested as a potential molecular target for anti-melanoma therapeutics. However, few …