[HTML][HTML] Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: Mitochondrion as a strategic target
D Lazarin-Bidóia, FP Garcia… - Memórias do Instituto …, 2022 - SciELO Brasil
Over the past years, natural products have been explored in order to find biological active
substances to treat various diseases. Regarding their potential action against parasites such …
substances to treat various diseases. Regarding their potential action against parasites such …
Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS …
KD Rodríguez-Hernández, I Martínez… - Bioorganic …, 2020 - Elsevier
Chagas Disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi which affects 6–8 million people, mostly in Latin America. The medical …
Trypanosoma cruzi which affects 6–8 million people, mostly in Latin America. The medical …
Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages
SS Grecco, TA Costa-Silva, G Jerz, FS de Sousa… - Chemico-biological …, 2017 - Elsevier
Chagas disease is a neglected tropical disease, caused by the protozoan parasite
Trypanosoma cruzi, which affects more than eight million people in Tropical and Subtropical …
Trypanosoma cruzi, which affects more than eight million people in Tropical and Subtropical …
[PDF][PDF] The uniqueness of the trypanosoma cruzi mitochondrion: opportunities to target new drugs against chagas disease
LS Paes, BS Mantilla, MJ Barisón… - Current …, 2011 - researchgate.net
Trypanosoma cruzi is the causative agent of Chagas disease, which affects some 8–10
million people in the Americas. The only two drugs approved for the etiological treatment of …
million people in the Americas. The only two drugs approved for the etiological treatment of …
[HTML][HTML] Anti-trypanosoma activity and synergistic effects of natural and semi-synthetic triterpenes and predominant cell death through autophagy in amastigote forms
GDP Bossolani, T Ueda-Nakamura, SO Silva… - Journal of the Brazilian …, 2017 - SciELO Brasil
Chagas' disease is a parasitic disease with unsatisfactory treatment, mainly in chronic stage.
This study aimed to evaluate the trypanocidal activity and action mechanisms of α/β-amyrin …
This study aimed to evaluate the trypanocidal activity and action mechanisms of α/β-amyrin …
[HTML][HTML] Is the mitochondrion a promising drug target in trypanosomatids?
Y Pedra-Rezende, ACS Bombaça… - Memórias do Instituto …, 2022 - SciELO Brasil
The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are
etiological agents of important neglected tropical diseases, affecting millions of people …
etiological agents of important neglected tropical diseases, affecting millions of people …
The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi
P Veiga-Santos, VC Desoti, N Miranda… - Acta tropica, 2013 - Elsevier
The currently available treatments for Chagas disease show limited therapeutic potential
and are associated with serious side effects. Our group has been attempting to find …
and are associated with serious side effects. Our group has been attempting to find …
[HTML][HTML] Leishmaniasis and Chagas disease chemotherapy: a critical review
I Silva-Jardim, OH Thiemann, FF Anibal - Journal of the Brazilian …, 2014 - SciELO Brasil
Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp
and Trypanosoma cruzi, respectively, are among the most important parasitic diseases …
and Trypanosoma cruzi, respectively, are among the most important parasitic diseases …
Mitochondria and trypanosomatids: targets and drugs
LM Fidalgo, L Gille - Pharmaceutical research, 2011 - Springer
The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: sleeping sickness, Chagas diseases and leishmaniasis …
infectious diseases in humans: sleeping sickness, Chagas diseases and leishmaniasis …
The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas' Disease
L Silva Paes, B Suarez Mantilla… - Current …, 2011 - ingentaconnect.com
Trypanosoma cruzi is the causative agent of Chagas' disease, which affects some 8-10
million people in the Americas. The only two drugs approved for the etiological treatment of …
million people in the Americas. The only two drugs approved for the etiological treatment of …