Antiviral approaches against influenza virus

R Kumari, SD Sharma, A Kumar, Z Ende… - Clinical microbiology …, 2023 - Am Soc Microbiol
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

[HTML][HTML] Advancements in host-based interventions for influenza treatment

TF Yip, ASM Selim, I Lian, SMY Lee - Frontiers in immunology, 2018 - frontiersin.org
Influenza is a major acute respiratory infection that causes mortality and morbidity
worldwide. Two classes of conventional antivirals, M2 ion channel blockers and …

Next-generation direct-acting influenza therapeutics

M Toots, RK Plemper - Translational Research, 2020 - Elsevier
Influenza viruses are a major threat to human health globally. In addition to further improving
vaccine prophylaxis, disease management through antiviral therapeutics constitutes an …

[HTML][HTML] Broadly protective strategies against influenza viruses: universal vaccines and therapeutics

OA Vogel, B Manicassamy - Frontiers in microbiology, 2020 - frontiersin.org
Influenza virus is a respiratory pathogen that can cause disease in humans, with symptoms
ranging from mild to life-threatening. The vast majority of influenza virus infections in …

New treatments for influenza

S Barik - BMC medicine, 2012 - Springer
Influenza has a long history of causing morbidity and mortality in the human population
through routine seasonal spread and global pandemics. The high mutation rate of the RNA …

[HTML][HTML] Influenza virus: a master tactician in innate immune evasion and novel therapeutic interventions

ACY Hsu - Frontiers in Immunology, 2018 - frontiersin.org
Influenza is a contagion that has plagued mankind for many decades, and continues to pose
concerns every year, with millions of infections globally. The frequent mutations and …

Pandemic and seasonal influenza: therapeutic challenges

MJ Memoli, DM Morens, JK Taubenberger - Drug discovery today, 2008 - Elsevier
Influenza A viruses cause significant morbidity and mortality annually, and the threat of a
pandemic underscores the need for new therapeutic strategies. Here, we briefly discuss …

[HTML][HTML] The next generation of influenza vaccines: Towards a universal solution

CLD McMillan, PR Young, D Watterson, KJ Chappell - Vaccines, 2021 - mdpi.com
Influenza viruses remain a constant burden in humans, causing millions of infections and
hundreds of thousands of deaths each year. Current influenza virus vaccine modalities …

Advances in the development of influenza virus vaccines

F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

Current and novel antiviral strategies for influenza infection

HL Yen - Current opinion in virology, 2016 - Elsevier
Highlights•Resistance and timely treatment are challenges for approved influenza
antivirals.•Structure insights on RNP functional domains aid development of novel …