The anti-CGRP antibody fremanezumab lowers CGRP release from rat dura mater and meningeal blood flow
M Dux, B Vogler, A Kuhn, KD Mackenzie, J Stratton… - Cells, 2022 - mdpi.com
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide
(CGRP) belong to a new generation of therapeutics that are effective in the prevention of …
(CGRP) belong to a new generation of therapeutics that are effective in the prevention of …
The anti-calcitonin gene-related peptide (anti-CGRP) antibody fremanezumab reduces trigeminal neurons immunoreactive to CGRP and CGRP receptor components …
B Vogler, A Kuhn, KD Mackenzie, J Stratton… - International Journal of …, 2023 - mdpi.com
Treatment with the anti-CGRP antibody fremanezumab is successful in the prevention of
chronic and frequent episodic migraine. In preclinical rat experiments, fremanezumab has …
chronic and frequent episodic migraine. In preclinical rat experiments, fremanezumab has …
Selective inhibition of trigeminovascular neurons by fremanezumab: a humanized monoclonal anti-CGRP antibody
A large body of evidence supports an important role for calcitonin gene-related peptide
(CGRP) in migraine pathophysiology. This evidence gave rise to a global effort to develop a …
(CGRP) in migraine pathophysiology. This evidence gave rise to a global effort to develop a …
CGRP function‐blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat
J Zeller, KT Poulsen, JE Sutton… - British journal of …, 2008 - Wiley Online Library
Background and purpose: Calcitonin gene‐related peptide (CGRP) receptor antagonists
effectively abort migraine headache and inhibit neurogenic vasodilatation in humans as well …
effectively abort migraine headache and inhibit neurogenic vasodilatation in humans as well …
CGRP monoclonal antibodies for migraine: rationale and progress
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …
and widely expressed in both the peripheral and central nervous systems, has recently …
Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other …
L Ohlsson, KA Haanes, E Kronvall, C Xu… - …, 2019 - journals.sagepub.com
Background Calcitonin gene-related peptide (CGRP) is a neuronal transmitter present in
intracranial sensory nerves, where it is involved in migraine pathophysiology as well as …
intracranial sensory nerves, where it is involved in migraine pathophysiology as well as …
Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier
Background The presence of calcitonin gene-related peptide and its receptors in multiple
brain areas and peripheral tissues previously implicated in migraine initiation and its many …
brain areas and peripheral tissues previously implicated in migraine initiation and its many …
Anti-CGRP and anti-CGRP receptor monoclonal antibodies as antimigraine agents. Potential differences in safety profile postulated on a pathophysiological basis
G Tringali, P Navarra - Peptides, 2019 - Elsevier
Calcitonin gene-related peptide (CGRP) is a peptide neurotransmitter with potent
vasodilating properties. CGRP is believed to play a primary role in the pathogenesis of …
vasodilating properties. CGRP is believed to play a primary role in the pathogenesis of …
Fremanezumab—a humanized monoclonal anti-CGRP antibody—inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
Fremanezumab inhibits vasodilatory effects of CGRP and capsaicin in rat cerebral artery-Potential role in conditions of severe vasoconstriction
AS Grell, KA Haanes, SE Johansson… - European Journal of …, 2019 - Elsevier
CGRP plays a major role in the pathophysiology of migraine. Concomitant, CGRP plays a
role in endogenous neurovascular protection from severe vasoconstriction associated with …
role in endogenous neurovascular protection from severe vasoconstriction associated with …