The rostral agranular insular cortex (RAIC) has been associated with pain modulation.
Although the endogenous cannabinoid system (eCB) has been shown to regulate chronic …

Selective activation of the peripheral cannabinoid receptor 1 (CB1R) has been shown to
suppress neuropathic pain symptoms in rodents. However, relatively little is known about …

Cannabinoids act on various regions in the nervous system to modulate neuronal activity
including nociception. Here, we investigated CB1 receptor expression in primary afferent …

Although regulation of nociceptive processes in the dorsal horn by deep brain structures has
long been established, the role of cortical networks in pain regulation is minimally explored …

Cannabinoid receptors have been identified as potential targets for analgesia from studies
on animal physiology and behavior, and from human clinical trials. Here, we sought to …

Cannabinoid CB1 receptors have analgesic effects in models of neuropathic pain, but can
also produce psychoactive side‐effects. A supraspinal location of CB2 receptors has …

Background Cannabinoid type-1 receptors (CB 1 Rs) are expressed in primary sensory
neurones, but their role in pain modulation remains unclear. Methods We produced Pirt-CB …

Background Preclinical and clinical evidence suggests that cannabis has potential
analgesic properties. However, cannabinoid receptor expression and localization within …

The rostral ventromedial medulla (RVM) is a relay in the descending pain modulatory
system and an important site of endocannabinoid modulation of pain. Endocannabinoids …

This study analyzed the effect of intra-ventrolateral periaqueductal grey (VL PAG)
cannabinoid receptor (CB) stimulation on pain responses and rostral ventromedial medulla …