Importance Alzheimer disease (AD) is now known to have a long preclinical phase in which
pathophysiologic processes develop many years, even decades, before the onset of clinical …

Objective Several studies have reported that non‐demented older adults with clinical
depression show changes in amyloid‐β (Aβ) levels in blood, cerebrospinal fluid and on …

Background: The detection of early Alzheimer's disease (AD) can rely on subjective and
informant reports of cognitive impairment. However, relationships between subjective …

Background High β-amyloid (Aβ) is associated with faster memory decline in healthy
individuals and adults with mild cognitive impairment (MCI). However, longer prospective …

Background This study tested if central obesity, hypertension, or depressive symptoms
moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance …

Objective To clarify the preclinical stage of Alzheimer's disease by estimating when β‐
amyloid accumulation first becomes associated with changes in cognition. Methods Here we …

Importance Depressive symptoms are prevalent among older adults and may be early
manifestations of Alzheimer disease (AD) before onset of mild cognitive impairment …

Late-life anxiety has been associated with increased progression from normal cognition to
amnestic MCI, suggesting that anxiety may be a neuropsychiatric symptom of Alzheimer's …

Objective To test the hypothesis that anxiety in amnestic mild cognitive impairment (aMCI)
increases rates of conversion to Alzheimer disease (AD) and to identify potential neural …

Importance The role of amyloid in the progression of Alzheimer disease (AD)
pathophysiology is of central interest to the design of randomized clinical trials. The …