mTOR signaling in cellular and organismal energetics
V Albert, MN Hall - Current opinion in cell biology, 2015 - Elsevier
Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in
a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can …
a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can …
Hypothalamic mTOR: the rookie energy sensor
PB Morentin, N Martinez-Sanchez… - Current molecular …, 2014 - ingentaconnect.com
Optimal cellular function and therefore organism's survival is determined by the sensitive
and accurate convergence of energy and nutrient abundance to cell growth and division …
and accurate convergence of energy and nutrient abundance to cell growth and division …
Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
Influence of mTOR in energy and metabolic homeostasis
M Haissaguerre, N Saucisse, D Cota - Molecular and cellular …, 2014 - Elsevier
The mechanistic (or mammalian) target of rapamycin couples a variety of different
environmental signals, including nutrients and hormones, with the regulation of several …
environmental signals, including nutrients and hormones, with the regulation of several …
mTOR at the nexus of nutrition, growth, ageing and disease
GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
mTORC1 signaling and the metabolic control of cell growth
I Ben-Sahra, BD Manning - Current opinion in cell biology, 2017 - Elsevier
mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of
mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient …
mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient …
[HTML][HTML] Activation of a metabolic gene regulatory network downstream of mTOR complex 1
K Düvel, JL Yecies, S Menon, P Raman, AI Lipovsky… - Molecular cell, 2010 - cell.com
Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a
common molecular event in a variety of pathological settings, including genetic tumor …
common molecular event in a variety of pathological settings, including genetic tumor …
An emerging role for TOR signaling in mammalian tissue and stem cell physiology
The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals,
ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors …
ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors …
mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases
Z Yang, XF Ming - Obesity Reviews, 2012 - Wiley Online Library
The continuing increase in the prevalence of obesity and metabolic disorders such as type‐II
diabetes and an accelerating aging population globally will remain the major contributors to …
diabetes and an accelerating aging population globally will remain the major contributors to …
TOR signaling in mammals
AC Carrera - Journal of cell science, 2004 - journals.biologists.com
4616 complex is required for mTOR-mediated S6K activation (Gonzalez-Garcia et al., 2002).
PI3K also mediates S6K activation via its effector, PDK1 (3-phosphoinositide-dependent …
PI3K also mediates S6K activation via its effector, PDK1 (3-phosphoinositide-dependent …