Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in
a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can …

Optimal cellular function and therefore organism's survival is determined by the sensitive
and accurate convergence of energy and nutrient abundance to cell growth and division …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

The mechanistic (or mammalian) target of rapamycin couples a variety of different
environmental signals, including nutrients and hormones, with the regulation of several …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of
mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient …

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a
common molecular event in a variety of pathological settings, including genetic tumor …

The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals,
ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors …

The continuing increase in the prevalence of obesity and metabolic disorders such as type‐II
diabetes and an accelerating aging population globally will remain the major contributors to …

4616 complex is required for mTOR-mediated S6K activation (Gonzalez-Garcia et al., 2002).
PI3K also mediates S6K activation via its effector, PDK1 (3-phosphoinositide-dependent …