Oxidative DNA damage is implicated in brain aging, neurodegeneration and neurological
diseases. Damage can be created by normal cellular metabolism, which accumulates with …

Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

As the population ages, age-related neurodegenerative diseases have become a major
challenge in health science. Currently, the pathology of neurodegenerative diseases, such …

Neurons are extremely active cells and metabolize up to 20% of the oxygen that was
consumed by the organism. Despite their highly oxygenic metabolism, neuronal cells have a …

Simple Summary Constant exposure to endogenous and environmental factors induces
oxidative stress and DNA damage. Rare brain disorders caused by defects in DNA repair …

Accumulation of oxidative DNA damage in the human brain has been implicated in
etiologies of post-traumatic and age-associated declines in neuronal function. In neurons …

Neuronal DNA repair remains one of the most exciting areas for investigation, particularly as
a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …

Stroke is a common cause of death and serious long-term adult disability. Oxidative DNA
damage is a severe consequence of oxidative stress associated with ischemic stroke. The …

A foremost challenge for the neurons, which are among the most oxygenated cells, is the
genome damage caused by chronic exposure to endogenous reactive oxygen species …