Spreading depression, spreading depolarizations, and the cerebral vasculature

C Ayata, M Lauritzen - Physiological reviews, 2015 - journals.physiology.org
Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Cortical spreading depolarization: Pathophysiology, implications, and future directions

DR Kramer, T Fujii, I Ohiorhenuan, CY Liu - Journal of Clinical …, 2016 - Elsevier
Cortical spreading depolarization (CSD) is a spreading loss of ion homeostasis, altered
vascular response, change in synaptic architecture, and subsequent depression in electrical …

Mechanisms of spreading depression and hypoxic spreading depression-like depolarization

GG Somjen - Physiological reviews, 2001 - journals.physiology.org
Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are
characterized by rapid and nearly complete depolarization of a sizable population of brain …

High-resolution in vivo imaging of the neurovascular unit during spreading depression

J Chuquet, L Hollender… - Journal of Neuroscience, 2007 - Soc Neuroscience
Spreading depression (SD) is a propagating wave of neuronal depolarization and ionic
shifts, seen in stroke and migraine. In vitro, SD is associated with astrocytic [Ca2+] waves …

Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression

JC Chang, LL Shook, J Biag, EN Nguyen, AW Toga… - Brain, 2010 - academic.oup.com
Cortical spreading depression is a propagating wave of depolarization that plays important
roles in migraine, stroke, subarachnoid haemorrhage and brain injury. Cortical spreading …

Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic …

M Lauritzen, JP Dreier, M Fabricius… - Journal of Cerebral …, 2011 - journals.sagepub.com
Cortical spreading depression (CSD) and depolarization waves are associated with
dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells …

Spreading depression and neurovascular coupling

C Ayata - Stroke, 2013 - Am Heart Assoc
S88 Stroke June 2013 or injury depolarizations. 19, 20 Interestingly, the vasoconstrictive
components are most conspicuous during the first spreading depression in naïve tissue, and …

[HTML][HTML] Migraine Aura, transient ischemic attacks, stroke, and dying of the brain share the same key pathophysiological process in neurons driven by gibbs–donnan …

CL Lemale, J Lückl, V Horst, C Reiffurth… - Frontiers in cellular …, 2022 - frontiersin.org
Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

[HTML][HTML] The stroke-migraine depolarization continuum

JP Dreier, C Reiffurth - Neuron, 2015 - cell.com
The term spreading depolarization (SD) refers to waves of abrupt, sustained mass
depolarization in gray matter of the CNS. SD, which spreads from neuron to neuron in …

Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression

N Zhou, GRJ Gordon, D Feighan, BA MacVicar - Cerebral cortex, 2010 - academic.oup.com
Cortical spreading depression (SD) is a propagating wave of neuronal and glial
depolarization that manifests in several brain disorders. However, the relative contribution of …