Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

How are transcription and processing of mRNA precursors co-ordinated? The past two years
has witnessed exciting insights into the mechanism which targets the mRNA processing …

Several observations made over the past year have forged strong molecular links between
transcription by RNA polymerase II (Pol II) and pre-mRNA processing. The key findings …

Capping, splicing, and cleavage/polyadenylation of pre-mRNAs are interdependent events
that are all stimulated in vivo by the carboxy-terminal domain (CTD) of RNA Pol II. We show …

Intense research in recent years has shown that many pre-mRNA processing events are co-
transcriptional or at least begin during RNA synthesis by RNA polymerase II (Pol II). But is it …

There is an emerging consensus that RNA polymerase II (RNA Pol II) transcription and pre-
mRNA processing are tightly coupled events. We show here that exons flanking an intron …

Many pre-mRNA processing events including 5′ end capping, splicing out introns, and 3′
end maturation by cleavage or polyadenylation occur while the nascent RNA chain is being …

We investigated the role of RNA polymerase II (pol II) carboxy-terminal domain (CTD)
phosphorylation in pre-mRNA processing coupled and uncoupled from transcription in …

Eukaryotic cells must execute a complex program to scripts engineered to be synthesized by
RNA polymergenerate mature functional messenger RNA (mRNA). ase III in mammalian …

The activities of several mRNA processing factors are coupled to transcription through
binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive …