Coupling mRNA processing with transcription in time and space
DL Bentley - Nature Reviews Genetics, 2014 - nature.com
Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
Coupling RNA polymerase II transcription with pre-mRNA processing.
D Bentley - Current opinion in cell biology, 1999 - europepmc.org
How are transcription and processing of mRNA precursors co-ordinated? The past two years
has witnessed exciting insights into the mechanism which targets the mRNA processing …
has witnessed exciting insights into the mechanism which targets the mRNA processing …
Transcription units as RNA processing units
KM Neugebauer, MB Roth - Genes & development, 1997 - genesdev.cshlp.org
Several observations made over the past year have forged strong molecular links between
transcription by RNA polymerase II (Pol II) and pre-mRNA processing. The key findings …
transcription by RNA polymerase II (Pol II) and pre-mRNA processing. The key findings …
Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD
N Fong, DL Bentley - Genes & development, 2001 - genesdev.cshlp.org
Capping, splicing, and cleavage/polyadenylation of pre-mRNAs are interdependent events
that are all stimulated in vivo by the carboxy-terminal domain (CTD) of RNA Pol II. We show …
that are all stimulated in vivo by the carboxy-terminal domain (CTD) of RNA Pol II. We show …
On the importance of being co-transcriptional
KM Neugebauer - Journal of cell science, 2002 - journals.biologists.com
Intense research in recent years has shown that many pre-mRNA processing events are co-
transcriptional or at least begin during RNA synthesis by RNA polymerase II (Pol II). But is it …
transcriptional or at least begin during RNA synthesis by RNA polymerase II (Pol II). But is it …
Exon tethering in transcription by RNA polymerase II
MJ Dye, N Gromak, NJ Proudfoot - Molecular cell, 2006 - cell.com
There is an emerging consensus that RNA polymerase II (RNA Pol II) transcription and pre-
mRNA processing are tightly coupled events. We show here that exons flanking an intron …
mRNA processing are tightly coupled events. We show here that exons flanking an intron …
The link between mRNA processing and transcription: communication works both ways
DAR Zorio, DL Bentley - Experimental cell research, 2004 - Elsevier
Many pre-mRNA processing events including 5′ end capping, splicing out introns, and 3′
end maturation by cleavage or polyadenylation occur while the nascent RNA chain is being …
end maturation by cleavage or polyadenylation occur while the nascent RNA chain is being …
RNA polymerase II carboxy-terminal domain phosphorylation is required for cotranscriptional pre-mRNA splicing and 3′-end formation
G Bird, DAR Zorio, DL Bentley - Molecular and cellular biology, 2004 - Am Soc Microbiol
We investigated the role of RNA polymerase II (pol II) carboxy-terminal domain (CTD)
phosphorylation in pre-mRNA processing coupled and uncoupled from transcription in …
phosphorylation in pre-mRNA processing coupled and uncoupled from transcription in …
Pre-mRNA processing and the CTD of RNA polymerase II: the tail that wags the dog?
EJ Steinmetz - Cell, 1997 - cell.com
Eukaryotic cells must execute a complex program to scripts engineered to be synthesized by
RNA polymergenerate mature functional messenger RNA (mRNA). ase III in mammalian …
RNA polymergenerate mature functional messenger RNA (mRNA). ase III in mammalian …
Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription
P Komarnitsky, EJ Cho, S Buratowski - Genes & development, 2000 - genesdev.cshlp.org
The activities of several mRNA processing factors are coupled to transcription through
binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive …
binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive …