Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

PR Jansen, M Nagel, K Watanabe, Y Wei… - Nature …, 2020 - nature.com
The phenotypic correlation between human intelligence and brain volume (BV) is
considerable (r≈ 0.40), and has been shown to be due to shared genetic factors. To further …

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …

B Zhao, T Luo, T Li, Y Li, J Zhang, Y Shan, X Wang… - Nature …, 2019 - nature.com
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …

Meta-analysis of associations between human brain volume and intelligence differences: How strong are they and what do they mean?

J Pietschnig, L Penke, JM Wicherts, M Zeiler… - Neuroscience & …, 2015 - Elsevier
Positive associations between human intelligence and brain size have been suspected for
more than 150 years. Nowadays, modern non-invasive measures of in vivo brain volume …

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

SJ van Der Lee, MJ Knol, G Chauhan… - Communications …, 2019 - nature.com
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-
wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 …

The causal influence of brain size on human intelligence: Evidence from within-family phenotypic associations and GWAS modeling

JJ Lee, M McGue, WG Iacono, AM Michael, CF Chabris - Intelligence, 2019 - Elsevier
There exists a moderate correlation between MRI-measured brain size and the general
factor of IQ performance (g), but the question of whether the association reflects a …

Big-brained people are smarter: A meta-analysis of the relationship between in vivo brain volume and intelligence

MA McDaniel - Intelligence, 2005 - Elsevier
The relationship between brain volume and intelligence has been a topic of a scientific
debate since at least the 1830s. To address the debate, a meta-analysis of the relationship …

Novel genetic loci underlying human intracranial volume identified through genome-wide association

HHH Adams, DP Hibar, V Chouraki, JL Stein… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and
remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes …

Are bigger brains smarter? Evidence from a large-scale preregistered study

G Nave, WH Jung, R Karlsson Linnér… - Psychological …, 2019 - journals.sagepub.com
A positive relationship between brain volume and intelligence has been suspected since the
19th century, and empirical studies seem to support this hypothesis. However, this claim is …

The association between brain volume and intelligence is of genetic origin

D Posthuma, EJC De Geus, WFC Baaré, HEH Pol… - Nature …, 2002 - nature.com
exposure to relevant environmental experience is under strong genetic control. The subjects
for whom MRI scans were available partly overlapped with a sample of extended twin …

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies

B Zhao, JG Ibrahim, Y Li, T Li, Y Wang, Y Shan… - Cerebral …, 2019 - academic.oup.com
Brain genetics is an active research area. The degree to which genetic variants impact
variations in brain structure and function remains largely unknown. We examined the …