Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …
strains of the same pathogenic species. We sequenced the whole genomes of 474 …
Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …
is often accompanied by a reduction in bacterial growth rate. This reduction has been …
Evolving stealth: Genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections
D Nguyen, PK Singh - … of the National Academy of Sciences, 2006 - National Acad Sciences
Most patients with the genetic disease cystic fibrosis (CF) succumb to chronic airway
infection caused by the bacterium Pseudomonas aeruginosa. CF lung disease follows a …
infection caused by the bacterium Pseudomonas aeruginosa. CF lung disease follows a …
Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients
Abstract Background Chronic infection with Pseudomonas aeruginosa is a major cause of
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …
Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …
airways has shown inefficient eradication of the infecting bacteria, as well as previously …
Parallel Evolution in Pseudomonas aeruginosa over 39,000 Generations In Vivo
ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …
Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic pathogen of humans and is a major cause of
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
EE Smith, DG Buckley, Z Wu… - Proceedings of the …, 2006 - National Acad Sciences
In many human infections, hosts and pathogens coexist for years or decades. Important
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception …
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception …
Dynamics of Pseudomonas aeruginosa genome evolution
One of the hallmarks of the Gram-negative bacterium Pseudomonas aeruginosa is its ability
to thrive in diverse environments that includes humans with a variety of debilitating diseases …
to thrive in diverse environments that includes humans with a variety of debilitating diseases …
Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung
J Diaz Caballero, ST Clark, B Coburn, Y Zhang… - MBio, 2015 - Am Soc Microbiol
Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …
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