Purpose In many previous experimental studies on multicellular tumor spheroids, the
spheroid diameter at which central necrosis develops has been determined to be twice the …

Growth curves for multicellular spheroids of 15 different tumor and normal cell lines were
characterized by doubling times which decreased with increasing growth until a stable …

A model for the growth of a tumor by diffusion is considered for spheroids which are grown in
a normal medium in suspension culture. The experimental evidence indicates that, upon the …

The multicell spheroid in vitro tumor model was used to study the effects of diffusion
limitations of metabolites on the development of necrosis in a tumor-like environment …

Multicell spheroids provide an in vitro tumour model of intermediate complexity between
tumours and standard cell cultures. Spheroids of several varieties of normal and tumour …

The in vitro growth of small (0.05 to 3 mm diameter) avascular multicellular tumor spheroids
from six rodent and two human tumor lines has been analyzed. Surprisingly, the radial …

Culturing of human tumor cells as multicellular spheroids can be a tool to study radiation
responses. The degree of structural and functional differentiation in the primary tumor may …

THIS COMMENTARY is focussed on recent publications about tumour spheroid technology
in cancer therapy research and mainly on those publications describing the effects of …

A model for the growth of spheroids including a recently discovered cell loss mechanism is
formulated. This model reproduces the observed growth patterns and predicts that, under …

Cell cycle kinetic parameters of multicell spheroids in vitro have been estimated using
thymidine labeling techniques and autoradiography. Both the mitotic index and thymidine …