Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Role of low-grade inflammation in osteoarthritis

CR Scanzello - Current opinion in rheumatology, 2017 - journals.lww.com
Role of low-grade inflammation in osteoarthritis : Current Opinion in Rheumatology Role of
low-grade inflammation in osteoarthritis : Current Opinion in Rheumatology Log in or Register …

Inflammation in osteoarthritis

MB Goldring, M Otero - Current opinion in rheumatology, 2011 - journals.lww.com
Further work on mediators and pathways that are common across different models and
occur in human osteoarthritis and that impact the osteoarthritis disease process at different …

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

M Rahmati, A Mobasheri, M Mozafari - Bone, 2016 - Elsevier
Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

Inflammation in osteoarthritis: the latest progress and ongoing challenges

AJ Knights, SJ Redding, T Maerz - Current opinion in …, 2023 - journals.lww.com
Osteoarthritis is a debilitating chronic disease that manifests with widely varying
symptomatology. Inflammation is now appreciated as a key pathophysiological process in …

Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis

A De Roover, A Escribano-Núñez… - Osteoarthritis and …, 2023 - Elsevier
Objectives As more has become known of the pathophysiology of osteoarthritis (OA),
evidence that inflammation plays a critical role in its development and progression has …

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

M Kapoor, J Martel-Pelletier, D Lajeunesse… - Nature Reviews …, 2011 - nature.com
Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

J Sokolove, CM Lepus - Therapeutic advances in …, 2013 - journals.sagepub.com
Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?

AS Siebuhr, AC Bay-Jensen, JM Jordan… - Scandinavian journal …, 2016 - Taylor & Francis
The disabling and painful disease osteoarthritis (OA) is the most common form of arthritis.
Strong evidence suggests that a subpopulation of OA patients has a form of OA driven by …

Prospects for disease modification in osteoarthritis

SB Abramson, M Attur, Y Yazici - Nature Clinical Practice …, 2006 - nature.com
Osteoarthritis (OA) can be a progressive, disabling disease, leading to diminished quality of
life, and, for over 500,000 individuals annually in the US, total joint replacement. The …