A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum

AA Morano, RM Rudlaff, JD Dvorin - Nature Communications, 2023 - nature.com
During its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of
daughter cells are formed within a single parent. The basal complex, a contractile ring that …

An essential contractile ring protein controls cell division in Plasmodium falciparum

RM Rudlaff, S Kraemer, VA Streva, JD Dvorin - Nature communications, 2019 - nature.com
During the blood stage of human malaria, Plasmodium falciparum parasites divide by
schizogony—a process wherein components for several daughter cells are produced within …

Protein phosphatase 1, a Plasmodium falciparum essential enzyme, is exported to the host cell and implicated in the release of infectious merozoites

T Blisnick, L Vincensini, G Fall… - Cellular …, 2006 - Wiley Online Library
The malarial parasite Plasmodium falciparumTransposes a Golgi‐like compartment, referred
to as Maurer's clefts, into the cytoplasm of its host cell, the erythrocyte, and delivering …

Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes

AS Paul, A Miliu, JA Paulo, JM Goldberg… - Nature …, 2020 - nature.com
Asexual proliferation of the Plasmodium parasites that cause malaria follows a
developmental program that alternates non-canonical intraerythrocytic replication with …

An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites

S Absalon, JA Robbins, JD Dvorin - Nature communications, 2016 - nature.com
Blood-stage replication of the human malaria parasite Plasmodium falciparum occurs via
schizogony, wherein daughter parasites are formed by a specialized cytokinesis known as …

Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum

IB Müller, J Knöckel, ML Eschbach… - Cellular …, 2010 - Wiley Online Library
As an intracellular proliferating parasite, Plasmodium falciparum exploits the human host to
acquire nutrients. However, nutrients such as nucleotides and cofactors are mostly …

Identification of basal complex protein that is essential for maturation of transmission-stage malaria parasites

RL Clements, AA Morano, FM Navarro… - Proceedings of the …, 2022 - National Acad Sciences
Malaria remains a global driver of morbidity and mortality. To generate new antimalarials,
one must elucidate the fundamental cell biology of Plasmodium falciparum, the parasite …

A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparum possesses tyrosine phosphatase activity and is implicated in the regulation of …

S Fernandez-Pol, Z Slouka, S Bhattacharjee… - Eukaryotic …, 2013 - Am Soc Microbiol
Eukaryotic parasites of the genus Plasmodium cause malaria by invading and developing
within host erythrocytes. Here, we demonstrate that PfShelph2, a gene product of …

The Plasmodium falciparum protein Pfg27 is dispensable for gametocyte and gamete production, but contributes to cell integrity during gametocytogenesis

A Olivieri, G Camarda, L Bertuccini… - Molecular …, 2009 - Wiley Online Library
In the human malaria parasite Plasmodium falciparum, gametocyte maturation is a process
remarkably longer than in other malaria species, accompanied by expression of 2–300 …

Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its …

R Kumar, B Adams, A Oldenburg, A Musiyenko, S Barik - Malaria Journal, 2002 - Springer
Background Reversible protein phosphorylation is relatively unexplored in the intracellular
protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong …