Design, Synthesis and Evaluation of Novel Phthalimide Derivatives as in Vitro Anti-Microbial, Anti-Oxidant and Anti-Inflammatory Agents
Sixteen new phthalimide derivatives were synthesized and evaluated for their in vitro anti-
microbial, anti-oxidant and anti-inflammatory activities. The cytotoxicity for all synthesized …
microbial, anti-oxidant and anti-inflammatory activities. The cytotoxicity for all synthesized …
New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2 …
NH Metwally, MS Mohamed - Bioorganic Chemistry, 2020 - Elsevier
Abstract New imidazol-5-one derivatives 12a, b and 12e, f, 14a, b and 16a, b were
synthesized and screened for their in vivo anti-inflammatory activity using a standard acute …
synthesized and screened for their in vivo anti-inflammatory activity using a standard acute …
Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1, 2-benzothiazine derivatives as novel anti-inflammatory agents
BM Szczęśniak-Sięga, B Wiatrak, Ż Czyżnikowska… - Bioorganic …, 2021 - Elsevier
Abstract Novel arylpiperazine-1, 2-benzothiazine derivatives have been designed and
synthesized as potential anti-inflammatory agents. Their structure and properties have been …
synthesized as potential anti-inflammatory agents. Their structure and properties have been …
New N-Substituted-1,2,4-triazole Derivatives of Pyrrolo[3,4-d]pyridazinone with Significant Anti-Inflammatory Activity—Design, Synthesis and Complementary In Vitro …
Ł Szczukowski, E Krzyżak, B Wiatrak, P Jawień… - International Journal of …, 2021 - mdpi.com
Regarding that the chronic use of commonly available non-steroidal and anti-inflammatory
drugs (NSAIDs) is often restricted by their adverse effects, there is still a current need to …
drugs (NSAIDs) is often restricted by their adverse effects, there is still a current need to …
An efficient synthesis of phthalimides and their biological activities
H Jelali, L Mansour, E Deniau, M Sauthier… - Polycyclic Aromatic …, 2022 - Taylor & Francis
Practical and efficient synthesis of phthalimides compounds 3 were described and
characterized. The synthesized compounds were screened for their antimicrobial activities …
characterized. The synthesized compounds were screened for their antimicrobial activities …
Design and synthesis of novel dithiazole carboxylic acid Derivatives: In vivo and in silico investigation of their Anti-Inflammatory and analgesic effects
Inflammation is a complex set of interactions that can occur in tissues as the body's
defensive response to infections, trauma, allergens, or toxic compounds. Therefore, in …
defensive response to infections, trauma, allergens, or toxic compounds. Therefore, in …
Design, synthesis, biological evaluation and in silico studies of novel pyrrolo [3, 4-d] pyridazinone derivatives with promising anti-inflammatory and antioxidant activity
Ł Szczukowski, A Redzicka, B Wiatrak, E Krzyżak… - Bioorganic …, 2020 - Elsevier
Novel Mannich base analogues of pyrrolo [3, 4-d] pyridazinone 7a, b-13a, b are designed
and synthesized as potential anti-inflammatory agents. The title compounds are obtained via …
and synthesized as potential anti-inflammatory agents. The title compounds are obtained via …
Docking study, synthesis, and anti-inflammatory potential of some new pyridopyrimidine-derived compounds
Background and Purpose Because of gastrointestinal irritation and kidney toxicity
associated with non-steroidal anti-inflammatory drugs and the cardiovascular problems of …
associated with non-steroidal anti-inflammatory drugs and the cardiovascular problems of …
Synthesis, pharmacological evaluation and docking studies of N-(benzo [d] thiazol-2-yl)-2-(piperazin-1-yl) acetamide analogs as COX-2 inhibitors
NM Raghavendra, A Jyothsna, AV Rao… - Bioorganic & medicinal …, 2012 - Elsevier
The existing NSAIDs having number of toxicities emphasises the need for discovery of new
non-toxic anti-inflammatory agents. In this Letter, we present the simple two step chemical …
non-toxic anti-inflammatory agents. In this Letter, we present the simple two step chemical …
Design, Synthesis, Molecular docking, and biological evaluation of novel 2, 3-diaryl-1, 3-thiazolidine-4-one derivatives as potential anti-inflammatory and cytotoxic …
YO Mekhlef, AM AboulMagd, AM Gouda - Bioorganic Chemistry, 2023 - Elsevier
Abstract A new series of 2, 3-diaryl-1, 3thiazolidin-4-one derivatives was designed,
synthesized, and evaluated for their cytotoxicity and COXs inhibitory activities. Among these …
synthesized, and evaluated for their cytotoxicity and COXs inhibitory activities. Among these …