High Throughput and Noninvasive Exosomal PD-L1 Detection for Accurate Immunotherapy Response Prediction via Tim4-Functionalized Magnetic Core–Shell Metal …

H Wang, Y Liu, L Zhang, X Li, G Zhao, Z Song… - Analytical …, 2023 - ACS Publications
Exosomal PD-L1 has been increasingly considered a noninvasive and accurate predictive
marker for immunotherapy treatment response. However, the clinical monitoring of exosomal …

Anti-Tim4 Grafting Strongly Hydrophilic Metal–Organic Frameworks Immunoaffinity Flake for High-Efficiency Capture and Separation of Exosomes

L Zhang, H Wang, G Zhao, N Li, X Wang, Y Li… - Analytical …, 2021 - ACS Publications
Exosomes have become the most ideal analysis target for liquid biopsy since they carry a
large amount of genetic materials. The study on exosomes has great significance for cancer …

Designed Directional Growth of Ti-Metal–Organic Frameworks for Decoding Alzheimer's Disease-Specific Exosome Metabolites

Y Chen, M Zhang, C Yang, M Gao, Y Yan… - Analytical …, 2024 - ACS Publications
Exosomes, a growing focus for liquid biopsies, contain diverse molecular cargos. In
particular, exosome metabolites with valuable information have exhibited great potential for …

Design and application of hydrophilic bimetallic metal-organic framework magnetic nanoparticles for rapid capture of exosomes

C Zhang, Y Pan, Y Zhao, P Wang, L Zhang… - Analytica Chimica Acta, 2021 - Elsevier
Functional materials with good biocompatibility have been widely used in the study of
genomics, proteomics and disease diagnosis, which has improved the progress of life …

Personalized detection of circling exosomal PD-L1 based on Fe3O4@ TiO2 isolation and SERS immunoassay

Y Pang, J Shi, X Yang, C Wang, Z Sun… - Biosensors and …, 2020 - Elsevier
Circling exosomal PD-L1 can be expected as a predictor for the clinical responds of anti-PD-
1/PD-L1 therapy. Here, we present a simple method integrating capture and analysis of …

PD-L1 exosomes electrochemical sensor based on coordination of AgNCs and Zr4+: Multivalent peptide enhancing target capture efficiency and antifouling …

J Hu, Z Mao, Y Lu, Q Chen, J Xia, H Deng… - Biosensors and …, 2023 - Elsevier
Programmed death ligand 1 (PD-L1) exosomes are important biomarkers of immune
activation in the initial stages of treatment and can predict clinical responses to PD-1 …

Ti3C2Tx MXene-facilitated non-selective trapping effect: efficient SERS detection of exosomal PD-L1

Y Zhou, Q Chen, S Zhong, H Liu, K Koh… - Biosensors and …, 2023 - Elsevier
Biosensors developed through a sandwich approach have demonstrated favorable
detection performance for exosomal programmed cell death 1 ligand 1 (ExoPD-L1) …

An integrated magneto-fluorescent nanosensor for rapid and sensitive detection of tumor-derived exosomes

S Luo, Y Wu, W Pan, G Zhong, B Situ, B Li, X Ye… - Sensors and Actuators B …, 2023 - Elsevier
Cancer released-exosomes containing specific surface proteins have high value in tumor
diagnosis and are considered a novel liquid biopsy biomarker. However, the development of …

Identification of programmed death ligand-1 positive exosomes in breast cancer based on DNA amplification-responsive metal-organic frameworks

Y Cao, Y Wang, X Yu, X Jiang, G Li, J Zhao - Biosensors and Bioelectronics, 2020 - Elsevier
Cancer-derived exosomes have recently emerged as potent candidates for diagnosis and
prognosis of breast cancer. As an example, programmed death ligand-1 positive (PD-L1+) …

Assembly of Nanocatalyst As a Noninvasive Tool for Breast Cancer Diagnosis and Immunotherapy Surveillance Designed by Visually Tracking Tumor-Derived …

H Shi, T Zeng, Y Liu, Q Liang, F Yang… - ACS Materials …, 2022 - ACS Publications
Immunotherapy has reshaped the therapeutic landscape of many advanced tumors;
however, its effectiveness is seriously hampered due to the limitations of existing predictors …