DNA topoisomerases are essential enzymes that regulate DNA topology, the transmission of
genetic materials, and gene expressions both in the nucleus and mitochondria. Trapped …

Topoisomerase poisons act by inducing abortive topoisomerase reactions, which generate
stable protein–DNA breaks (PDBs) that interfere with transcription elongation and …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes
(Top1cc) by hydrolyzing their 3′-phosphotyrosyl DNA bonds and repairs bleomycin …

Abstract Tyrosyl DNA phosphodiesterase 2 (TDP2) is a multifunctional protein implicated in
DNA repair, signal transduction and transcriptional regulation. In its DNA repair role, TDP2 …

Human tyrosyl–DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a
DNA 3′ end linked to a tyrosyl moiety. This type of linkage is found at stalled …

Abstract Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a DNA repair enzyme that removes
irreversible protein-linked 3′ DNA complexes, 3′ phosphoglycolates, alkylation damage …

Abstract Topoisomerase I (TOP1) resolves DNA topology during replication and
transcription. The enzyme forms an intermediate TOP1 cleavage complex (TOP1cc) through …

The generation of elevated levels of enzyme-DNA covalent complexes is the key event in
cell killing by many drugs targeting DNA topoisomerases. These agents, termed …

Abstract Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked
adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent …

Abstract Mammalian Tyrosyl-DNA phosphodiesterase 2 (Tdp2) reverses Topoisomerase 2
(Top2) DNA–protein crosslinks triggered by Top2 engagement of DNA damage or poisoning …