Consensus on biomarkers for neuroendocrine tumour disease

K Oberg, IM Modlin, W De Herder, M Pavel… - The Lancet …, 2015 - thelancet.com
Management of neuroendocrine neoplasia represents a clinical challenge because of its
late presentation, lack of treatment options, and limitations in present imaging modalities …

Neuroendocrine tumor biomarkers: From monoanalytes to transcripts and algorithms

IM Modlin, L Bodei, M Kidd - … practice & research Clinical endocrinology & …, 2016 - Elsevier
The management of neuroendocrine neoplasia remains a perplexing problem because of
the lack of knowledge of the biology of the disease, its late presentation, the relative …

Neuroendocrine tumor biomarkers: current status and perspectives

IM Modlin, K Oberg, A Taylor, I Drozdov, L Bodei… - …, 2015 - karger.com
The identification of accurate harbingers of disease status and therapeutic efficacy are
critical requirements in precise diagnosis and effective management. Initially, tissue analysis …

Role of biomarker tests for diagnosis of neuroendocrine tumours

J Hofland, WT Zandee, WW de Herder - Nature Reviews Endocrinology, 2018 - nature.com
Neuroendocrine tumours (NETs) are neoplasms that arise from neuroendocrine cells.
Neuroendocrine cells and their tumours can secrete a wide range of amines and …

ENETS consensus guidelines for the standards of care in neuroendocrine tumors: biochemical markers

D O'Toole, A Grossman, D Gross, G Delle Fave… - …, 2009 - karger.com
The overall sensitivity and specificity of urinary 5-HIAA in the presence of the carcinoid
syndrome is of the order of 70 and 90%, respectively [1, 2]. Midgut carcinoids are most liable …

Neuroendocrine tumor heterogeneity adds uncertainty to the World Health Organization 2010 Classification: real‐world data from the Spanish Tumor Registry (R …

B Nuñez‐Valdovinos, A Carmona‐Bayonas… - The …, 2018 - academic.oup.com
Background Gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are a
complex family of tumors of widely variable clinical behavior. The World Health Organization …

Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set

DS Klimstra, IR Modlin, NV Adsay… - The American journal …, 2010 - journals.lww.com
Epithelial neuroendocrine tumors (NETs) have been the subject of much debate regarding
their optimal classification. Although multiple systems of nomenclature, grading, and staging …

Algorithmic approach to neuroendocrine tumors in targeted biopsies: practical applications of immunohistochemical markers

K Duan, O Mete - Cancer cytopathology, 2016 - Wiley Online Library
Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms with distinct
biological behaviors, depending on the site of origin and the degree of tumor proliferation …

The NETest: the clinical utility of multigene blood analysis in the diagnosis and management of neuroendocrine tumors

IM Modlin, M Kidd, A Malczewska… - Endocrinology and …, 2018 - endo.theclinics.com
Neuroendocrine neoplasms (NENs), also called neuroendocrine tumors (NETs), and
generically referred to as “carcinoids,” represent a spectrum of tumors with a diverse range …

Molecular profiling of neuroendocrine malignancies to identify prognostic and therapeutic markers: a Fox Chase Cancer Center Pilot Study

N Vijayvergia, PM Boland, E Handorf… - British journal of …, 2016 - nature.com
Background: The rarity of neuroendocrine malignancies limits the ability to develop new
therapies and thus a better understanding of the underlying biology is critical. Methods …