Clinical use of molecular data in thyroid nodules and cancer

AS Alzahrani - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Over the past 3 decades, advances in the molecular genetics of thyroid cancer (TC) have
been translated into diagnostic tests, prognostic markers, and therapeutic agents. The main …

Clinical value of molecular markers as diagnostic and prognostic tools to guide treatment of thyroid cancer

P Valderrabano, M Eszlinger… - Clinical …, 2023 - Wiley Online Library
Objective Advances in our understanding of the molecular biology of thyroid tumours is
being rapidly translated into their clinical management. This review summarizes the current …

[HTML][HTML] Update on molecular diagnostics in thyroid pathology: a review

B Alzumaili, PM Sadow - Genes, 2023 - mdpi.com
Thyroid nodules are quite common, and the determination of a nodule of concern is
complex, involving serum testing, radiology and, in some cases, pathological evaluation. For …

[HTML][HTML] Molecular approaches to thyroid cancer diagnosis

SJ Hsiao, YE Nikiforov - Endocrine-related cancer, 2014 - erc.bioscientifica.com
Thyroid nodules are common, and the accurate diagnosis of cancer or benign disease is
important for the effective clinical management of patients. Molecular markers are a helpful …

Molecular testing in thyroid cancer diagnosis and management

JA Sipos, MD Ringel - Best Practice & Research Clinical Endocrinology & …, 2023 - Elsevier
Molecular diagnostic testing has had a profound impact on the diagnosis and management
of thyroid nodules and thyroid cancer. Based on the tremendous expansion of knowledge of …

Ruling in or ruling out thyroid malignancy by molecular diagnostics of thyroid nodules

M Eszlinger, L Hegedüs, R Paschke - Best practice & research Clinical …, 2014 - Elsevier
Routine morphologic cytology is the basis for any kind of (integrated) molecular FNA
diagnostics. The rule out (gene expression classifier) approach requires confirmation by …

Diagnostic use of molecular markers in the evaluation of thyroid nodules

MI Kim, EK Alexander - Endocrine Practice, 2012 - Elsevier
Objective To describe the molecular markers thus far evaluated for use in the care of
patients with clinically relevant thyroid nodules. Methods We review the currently available …

[HTML][HTML] Genomic profiling of thyroid nodules: current role for ThyroSeq next-generation sequencing on clinical decision-making

AY Kargi, MP Bustamante, S Gulec - Molecular imaging and …, 2017 - ncbi.nlm.nih.gov
In recent years there has been an increased awareness of the genetic alterations underlying
both benign and malignant neoplasms of the thyroid. Next-generation sequencing (NGS) is …

The role of genetic markers in the evaluation and management of thyroid nodules

S Parangi, H Suh - Surgical Clinics, 2014 - surgical.theclinics.com
Background The role of commonly associated genetic mutations in thyroid cancer is being
actively investigated. However, the role of genetic alterations in tumorigenesis, the …

[HTML][HTML] Molecular diagnostics in the evaluation of thyroid nodules: Current use and prospective opportunities

J Patel, J Klopper, EE Cottrill - Frontiers in endocrinology, 2023 - frontiersin.org
Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new
cases to be diagnosed in 2022 and representing the 7th most common cancer in women …