Metabolomics in systems biology

W Weckwerth - Annual review of plant biology, 2003 - annualreviews.org
The primary aim of “omic” technologies is the nontargeted identification of all gene products
(transcripts, proteins, and metabolites) present in a specific biological sample. By their …

Plant metabolomics and its potential for systems biology research: Background concepts, technology, and methodology

JW Allwood, RCH De Vos, A Moing, C Deborde… - Methods in …, 2011 - Elsevier
The “metabolome” comprises the entire complement of small molecules in a plant or any
other organism. It represents the ultimate phenotype of cells, deduced from the perturbation …

Integrated omics approaches in plant systems biology

A Fukushima, M Kusano, H Redestig, M Arita… - Current opinion in …, 2009 - Elsevier
Understanding cellular metabolic systems is vital not only for determining the function of
enzymatic genes, but also for elucidating the coordination among various metabolic …

Integration of metabolomics data into metabolic networks

N Töpfer, S Kleessen, Z Nikoloski - Frontiers in plant science, 2015 - frontiersin.org
Metabolite levels together with their corresponding metabolic fluxes are integrative
outcomes of biochemical transformations and regulatory processes and they can be used to …

Plant metabolomics: current initiatives and future prospects

S Manickam, VR Rajagopalan, R Kambale… - Current Issues in …, 2023 - mdpi.com
Plant metabolomics is a rapidly advancing field of plant sciences and systems biology. It
involves comprehensive analyses of small molecules (metabolites) in plant tissues and …

Can we discover novel pathways using metabolomic analysis?

W Weckwerth, O Fiehn - Current opinion in biotechnology, 2002 - Elsevier
Metabolomic analysis aims at the identification and quantitation of all metabolites in a given
biological sample. Current data acquisition and network analysis strategies are classified on …

Metabolomics for functional genomics, systems biology, and biotechnology

K Saito, F Matsuda - Annual review of plant biology, 2010 - annualreviews.org
Metabolomics now plays a significant role in fundamental plant biology and applied
biotechnology. Plants collectively produce a huge array of chemicals, far more than are …

Recent progress in the development of metabolome databases for plant systems biology

A Fukushima, M Kusano - Frontiers in plant science, 2013 - frontiersin.org
Metabolomics has grown greatly as a functional genomics tool, and has become an
invaluable diagnostic tool for biochemical phenotyping of biological systems. Over the past …

Plant metabolomics: towards biological function and mechanism

N Schauer, AR Fernie - Trends in plant science, 2006 - cell.com
Metabolite profiling is a fast growing technology and is useful for phenotyping and
diagnostic analyses of plants. It is also rapidly becoming a key tool in functional annotation …

Metabolomics: an integral technique in systems biology

W Weckwerth - Bioanalysis, 2010 - Taylor & Francis
Metabolomics is the unbiased identification and state-specific quantification of all
metabolites in a cell, tissue or whole organism, and has developed rapidly into one of the …