While 3D chromatin organization in topologically associating domains (TADs) and loops
mediating regulatory element-promoter interactions is crucial for tissue-specific gene …

Congenital heart disease (CHD) is the most common form of birth defect and is the leading
noninfectious cause of infant death. A growing body of evidence demonstrates that genetic …

Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic
mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these …

Pitx2 is a bicoid-related homeodomain transcription factor that plays a critical role in
directing cardiac asymmetric morphogenesis. Ectopic Pitx2c expression in the developing …

The Pitx2 gene encodes a homeobox transcription factor that is required for mammalian
development. Disruption of PITX2 expression in humans causes congenital heart diseases …

Background—Pitx2 is a homeobox transcription factor that plays a pivotal role in early
left/right determination during embryonic development. Pitx2 loss-of-function mouse mutants …

Publisher Summary This chapter discusses the importance of Pitx2 in cardiac left-right
asymmetry and human disease. Left–right asymmetry defects were recognized to be a …

In this issue of Circulation Research, Tessari et al1 inves-tigate the role of an interesting
gene, Pitx2, which acts in breaking symmetry in early development and has subsequent …

To aid in detection and tracking of cells targeted by the left‐right (LR) pathway in the heart
throughout morphogenesis, expression from a Pitx2c‐lacZ transgene (P2Ztg) was analysed …

Pitx2 is a homeobox transcription factor involved in left–right signaling during
embryogenesis. Disruption of left–right signaling in mice within its core nodal/lefty cascade …