Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a
critical regulator of adaptive immune responses. Cbl-b is essential for establishing the …

Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein
ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell …

The distinction of self from non-self is crucial to prevent autoreactivity and ensure protection
from infectious agents and tumors. Maintaining the balance between immunity and tolerance …

The family of the Casitas B-lineage Lymphoma (Cbl) proteins, c-Cbl, Cbl-b, and Cbl-3,
function as E3 ubiquitin ligases and molecular adaptors. In particular, Cbl-b acts as a …

Maintenance of immunological tolerance is a critical hallmark of the immune system. Several
signaling checkpoints necessary to balance activating and inhibitory input to immune cells …

E3 ubiquitin ligases have been placed among the essential molecules involved in the
regulation of T cell functions and T cell tolerance. However, it has never been experimentally …

E3 ubiquitin ligase Cbl-b has emerged as a gatekeeper that controls the activation threshold
of the T cell antigen receptor and maintains the balance between tolerance and …

Peripheral activation of antigen-specific T cells is stringently controlled to prevent immune
responses against self-antigens. Only after a T cell is presented with two signals, an antigen …

The E3 ubiquitin ligase Casitas B-lineage lymphoma (Cbl-b) is central to antigen-induced
immune tolerance and regulates the CD28 dependence of T cell activation. Cbl-b …

Ubiquitination is a form of posttranslational protein modification that affects the activity of
target proteins by regulating their intracellular degradation, trafficking, localization, and …