Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to
cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by …

BNIP3 is an atypical BH3-only member of the Bcl-2 family with pro-death, pro-autophagic,
and cytoprotective functions, depending on the type of stress and cellular context. Recently …

Background/Aims: The maximum lifespan of the naked mole rat is over 28.3 years, which
exceeds that of any other rodent species, suggesting that age-related changes in its body …

Background/Aims: Naked mole rats (NMRs) survive and thrive in dark, dank environments
with low levels of oxygen and poor quality nutrition. Their long lifespan is attributed to …

Loganin is a type of iridoid glycosides isolated from Corni fructus and is known to have
various pharmacological properties, but studies on its antioxidant activity are still lacking …

Hypoxia in tumors is known to trigger the pro-survival pathways such as autophagy.
Systemic proopiomelanocortin (POMC) gene therapy suppresses melanoma through …

Bone marrow‐derived mesenchymal stem cells (BM‐MSCs) have been demonstrated as an
ideal autologous stem cells source for cell‐based therapy for myocardial infarction (MI) …

Studies have established that autophagy constitutes an efficient process to recycle cellular
components and certain proteins. The phenomenon was demonstrated primarily in …

Abstract Hydrogen peroxide (H2O2) is an extremely reactive oxidoradical that is normally
produced as a by-product of the mitochondrial activity and also under several metabolic …

Hypoxia is widely accepted as a fundamental biological phenomenon, which is strongly
associated with tissue damage and cell viability under stress conditions. Insulin-like growth …