[HTML][HTML] DNA Hypomethylation Is Associated with Increased Inflammation in Peripheral Blood Neutrophils of Children with Autism Spectrum Disorder: Understanding …

AA Alshamrani, S Alshehri, SS Alqarni, SF Ahmad… - Metabolites, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a multidimensional disorder in which environmental,
immune, and genetic factors act in concert to play a crucial role. ASD is characterized by …

Dysregulated Nrf2 signaling in response to di (2-ethylhexyl) phthalate in neutrophils of children with autism

A Nadeem, SF Ahmad, NO Al-Harbi… - International …, 2022 - Elsevier
Autism spectrum disorder (ASD) is characterized by constellation of impaired behaviors that
include deficits in social interaction/communication and the presence of restricted/repetitive …

Exposure to the plasticizer, Di-(2-ethylhexyl) phthalate during juvenile period exacerbates autism-like behavior in adult BTBR T+ tf/J mice due to DNA hypomethylation …

A Nadeem, NO Al-Harbi, SF Ahmad, K Alhazzani… - Progress in Neuro …, 2021 - Elsevier
Epigenetic modifications are known to play a crucial role in the behavioral modifications
through regulation of gene expression. Environmental factors are known to regulate genetic …

[HTML][HTML] The promise of DNA methylation in understanding multigenerational factors in autism spectrum disorders

JS Mouat, JM LaSalle - Frontiers in Genetics, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized
by impairments in social reciprocity and communication, restrictive interests, and repetitive …

[HTML][HTML] DNA Methylation Biomarkers for Young Children with Idiopathic Autism Spectrum Disorder: A Systematic Review

A Stoccoro, E Conti, E Scaffei, S Calderoni… - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, the underlying
pathological mechanisms of which are not yet completely understood. Although several …

Altered DNA methylation in a severe subtype of idiopathic autism: Evidence for sex differences in affected metabolic pathways

VW Hu, Y Hong, M Xu, HT Shu - Autism, 2021 - journals.sagepub.com
Although differences in DNA methylation have been associated with both syndromic and
idiopathic autism, differential methylation has not been examined previously with respect to …

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

KP Keil, PJ Lein - Environmental epigenetics, 2016 - academic.oup.com
There is now compelling evidence that gene by environment interactions are important in
the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which …

[HTML][HTML] A history of childhood maltreatment is associated with altered DNA methylation levels of DNA methyltransferase 1 in maternal but not neonatal mononuclear …

RN Mavioglu, L Ramo-Fernandez, AM Gumpp… - Frontiers in …, 2022 - frontiersin.org
Childhood maltreatment (CM) is associated with alterations in DNA methylation (DNAm)
especially in stress response genes. Due to the higher risk of overall health complications of …

Ubiquitous plasticizer, Di-(2-ethylhexyl) phthalate enhances existing inflammatory profile in monocytes of children with autism

A Nadeem, SF Ahmad, NO Al-Harbi, LY Al-Ayadhi… - Toxicology, 2020 - Elsevier
Genetic as well as environmental factors are believed to play a significant role in the
pathogenesis and progression of autism spectrum disorder (ASD). Phthalates are ubiquitous …

Aggravation of autism-like behavior in BTBR T+ tf/J mice by environmental pollutant, di-(2-ethylhexyl) phthalate: Role of nuclear factor erythroid 2-related factor 2 and …

A Nadeem, SF Ahmad, NO Al-Harbi, SM Attia… - International …, 2021 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder which manifests
itself in early childhood and is distinguished by recurring behavioral patterns, and …