Iron metabolism: pathophysiology and pharmacology

K Roemhild, F von Maltzahn, R Weiskirchen… - Trends in …, 2021 - cell.com
Iron is essential in many physiological processes, including DNA metabolism, oxygen
transport, and cellular energy generation. Deregulated iron metabolism, which results in iron …

Targeting iron metabolism in drug discovery and delivery

BJ Crielaard, T Lammers, S Rivella - Nature Reviews Drug Discovery, 2017 - nature.com
Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities

U Abbasi, S Abbina, A Gill, LE Takuechi… - ACS Chemical …, 2021 - ACS Publications
Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved
in vital cellular processes. The iron economy within humans is highly conserved in that there …

Iron metabolism and toxicity

G Papanikolaou, K Pantopoulos - Toxicology and applied pharmacology, 2005 - Elsevier
Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a
threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's …

[HTML][HTML] The role of iron regulation in immunometabolism and immune-related disease

SJF Cronin, CJ Woolf, G Weiss… - Frontiers in molecular …, 2019 - frontiersin.org
Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

[HTML][HTML] Balancing acts: molecular control of mammalian iron metabolism

MW Hentze, MU Muckenthaler, NC Andrews - cell, 2004 - cell.com
Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on
physiology and homeostasis—understanding how cells and organisms regulate their iron …

[HTML][HTML] Altered iron metabolism and impact in cancer biology, metastasis, and immunology

RAM Brown, KL Richardson, TD Kabir, D Trinder… - Frontiers in …, 2020 - frontiersin.org
Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

[图书][B] Iron metabolism: from molecular mechanisms to clinical consequences

R Crichton - 2016 - books.google.com
Iron is indispensable for the growth, development and well-being of almost all living
organisms. Biological systems from bacteria, fungi and plants to humans have evolved …

Iron is hot: an update on the pathophysiology of hemochromatosis

NC Andrews, JE Levy - Blood, The Journal of the American …, 1998 - ashpublications.org
GENETIC IRON OVERLOAD disorders are prevalent yet poorly understood. Over the past 3
years, the discoveries of the hereditary hemochromatosis gene and an intestinal iron …

New insights into iron regulation and erythropoiesis

A Kim, E Nemeth - Current opinion in hematology, 2015 - journals.lww.com
New insights into iron regulation and erythropoiesis : Current Opinion in Hematology New
insights into iron regulation and erythropoiesis : Current Opinion in Hematology Log in or …