Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Tumor angiogenesis is a fast growing sub-domain of angiogenesis research and tumor
biology. Basic mechanisms have been unraveled and many key players identified. For many …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

The growth and dissemination of tumors rely on an altered vascular network, which supports
their survival and expansion and provides accessibility to the vasculature and a route of …

The establishment of a functional, integrated vascular system is instrumental for tissue
growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be …

Tumors have been recently recognized as aberrant organs composed of a complex mixture
of highly interactive cells that in addition to the cancer cell include stroma (fibroblasts …

Targeting the tumor vasculature to “starve a tumor to death” instead of targeting tumor cells
with chemotherapeutic drugs was conceived over four decades ago and has led to the …

Targeting angiogenesis represents a new strategy for the development of anticancer
therapies. New targets derived from proliferating endothelial cells may be useful in …

All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …