Monoclonal antibodies have been applied clinically to the diagnosis and therapy of an array
of human disorders, including cancer and infectious diseases, and have been used for the …

In a relatively short period of time, monoclonal antibodies have entered the mainstream of
cancer therapy. Their first use was as antagonists of oncogenic receptor tyrosine kinases …

For more than a century, doctors have dreamt of using antibodies as' magic bullets' to cure
their patients. After all, these highly targeted proteins are among the immune system's key …

Published by AAAS tumors more effectively (7). However, such molecules are rapidly
cleared and lack effector functions. Hence, they can only kill tumor cells if they bind to target …

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery,
development, and clinical applications while incorporating principles, experimental data …

Over the last three decades, monoclonal antibodies have made a dramatic transformation
from scientific tools to powerful human therapeutics. At present, approximately 30 …

Fig. 1 Monoclonal antibodies can block tumor growth using many mechanisms. Top,
monoclonal antibodies recognize antigens on the target cell, in this case a cancer cell. 1 …

Monoclonal antibody (mAb) therapy has been facilitated by a number of technologic
advances over the past 30 years. Whereas hybridoma development of murine mAbs was …

Attention to therapeutic monoclonal antibodies has been dramatically increasing year by
year. Their highly specific targeting of antigens can provide very effective medical treatment …

The specificity of antibodies has been harnessed to target cancer cells and the first
therapeutic antibodies for use in oncology are now finding application in the clinic. Studies …