Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment

N Fayazi, M Sheykhhasan, S Soleimani Asl… - Molecular …, 2021 - Springer
Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …

Potential therapies by stem cell‐derived exosomes in CNS diseases: Focusing on the neurogenic niche

A Luarte, LF Bátiz, U Wyneken… - Stem cells …, 2016 - Wiley Online Library
Neurodegenerative disorders are one of the leading causes of death and disability and one
of the biggest burdens on health care systems. Novel approaches using various types of …

The therapeutic potential of mesenchymal stem cell–derived exosomes in treatment of neurodegenerative diseases

AM Gorabi, N Kiaie, GE Barreto, MI Read, HA Tafti… - Molecular …, 2019 - Springer
Neurologic complications are commonly regarded as irreversible impairments that stem from
limited potential of regeneration of the central nervous system (CNS). On the other side, the …

Promising opportunities for treating neurodegenerative diseases with mesenchymal stem cell-derived exosomes

R Guy, D Offen - Biomolecules, 2020 - mdpi.com
Neurodegenerative disease refers to any pathological condition in which there is a
progressive decline in neuronal function resulting from brain atrophy. Despite the immense …

Exosomes as a potential novel therapeutic tools against neurodegenerative diseases

A Jarmalavičiūtė, A Pivoriūnas - Pharmacological research, 2016 - Elsevier
Exosomes are extracellular vesicles that can transfer biological information over long
distances affecting normal and pathological processes throughout organism. It is known that …

Exosomes and stem cells in degenerative disease diagnosis and therapy

YH Chang, KC Wu, HJ Harn, SZ Lin… - Cell …, 2018 - journals.sagepub.com
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's
disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction …

Exosomes-based nanomedicine for neurodegenerative diseases: current insights and future challenges

A Cano, Á Muñoz-Morales, E Sánchez-López… - Pharmaceutics, 2023 - mdpi.com
Neurodegenerative diseases constitute a group of pathologies whose etiology remains
unknown in many cases, and there are no treatments that stop the progression of such …

Perspective insights of exosomes in neurodegenerative diseases: a critical appraisal

AT Jan, MA Malik, S Rahman, HR Yeo… - Frontiers in aging …, 2017 - frontiersin.org
Exosomes are small membranous entities of endocytic origin. Their production by a wide
variety of cells in eukaryotes implicates their roles in the execution of essential processes …

Extracellular vesicles: novel roles in neurological disorders

Q Jin, P Wu, X Zhou, H Qian, W Xu - Stem Cells International, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles (EVs) secreted by almost all cells, which have
been recognized as a novel platform for intercellular communication in the central nervous …

New therapeutic approaches of mesenchymal stem cells-derived exosomes

J Janockova, L Slovinska, D Harvanova… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the
treatment of several diseases due to their differentiation and immunomodulatory capabilities …