For the past 70 years, controversy about hypoglycemia in newborn infants has focused on a
numerical “definition of neonatal hypoglycemia”, without regard to its mechanism. This …

100 words). Our lack of basic knowledge about the basic mechanisms of transitional
hypoglycemia and other forms of hypoglycemia in newborns underlies the on-going …

A consistent definition for neonatal hypoglycemia in the first 48 h of life continues to elude
us. Enhanced understanding of metabolic disturbances and genetic disorders that underlie …

Hyperinsulinism is the single most common mechanism of hypoglycemia in neonates.
Dysregulated insulin secretion is responsible for the transient and prolonged forms of …

Maintenance of glucose homeostasis via initiation of glucose production is one of the critical
physiological events that results in a smooth transition and adaptation to extrauterine life. A …

Glucose is essential for cerebral metabolism. Unsurprisingly therefore, hypoglycemia may
result in encephalopathy. Knowledge of the homeostatic mechanisms that maintain blood …

Hyperinsulinaemic hypoglycaemia (HH) occurs as a consequence of unregulated insulin
secretion from pancreatic β cells. In the newborn period it is the most common cause of …

Purpose Molecular basis of various forms of hyperinsulinemic hypoglycemia, involving
defects in key genes regulating insulin secretion, are being increasingly reported. However …

Hypoglycemia is a heterogeneous disorder with many different possible etiologies, including
hyperinsulinism, glycogen storage disorders, fatty acid disorders, hormonal deficiencies …

Hypoglycemia continues to be an important cause of morbidity in neonates and children.
Prompt diagnosis and management of the underlying hypoglycemia disorder is critical for …