Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix
X Zhang, JM McLendon, BD Peck, B Chen… - … Therapy-Nucleic Acids, 2023 - cell.com
MicroRNAs (miRNAs) control the expression of diverse subsets of target mRNAs, and
studies have found miRNA dysregulation in failing hearts. Expression of miR-29 is abundant …
studies have found miRNA dysregulation in failing hearts. Expression of miR-29 is abundant …
[HTML][HTML] Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling
Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The
microRNA-29 (miR-29) family has been found to prevent excess collagen expression in …
microRNA-29 (miR-29) family has been found to prevent excess collagen expression in …
Inhibition of miR-15 protects against cardiac ischemic injury
TG Hullinger, RL Montgomery, AG Seto… - Circulation …, 2012 - Am Heart Assoc
Rationale: Myocardial infarction (MI) is a leading cause of death worldwide. Because
endogenous cardiac repair mechanisms are not sufficient for meaningful tissue …
endogenous cardiac repair mechanisms are not sufficient for meaningful tissue …
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
BC Bernardo, XM Gao, CE Winbanks… - Proceedings of the …, 2012 - National Acad Sciences
MicroRNAs are dysregulated in a setting of heart disease and have emerged as promising
therapeutic targets. MicroRNA-34 family members (miR-34a,-34b, and-34c) are up …
therapeutic targets. MicroRNA-34 family members (miR-34a,-34b, and-34c) are up …
Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo
N Abbas, JA Haas, K Xiao, M Fuchs, A Just… - European Heart …, 2024 - academic.oup.com
MicroRNA-21 (miR-21) plays a significant role in the regulation of fibrotic and inflammatory
gene expression signatures. Endogenous miR-21 shows robust expression in different types …
gene expression signatures. Endogenous miR-21 shows robust expression in different types …
MicroRNA-21–dependent macrophage-to-fibroblast signaling determines the cardiac response to pressure overload
D Ramanujam, AP Schön, C Beck, P Vaccarello… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac macrophages (cMPs) are increasingly recognized as important
regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these …
regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these …
MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease
EC Martinez, S Lilyanna, P Wang, LA Vardy… - Journal of molecular and …, 2017 - Elsevier
Rationale Myocardial infarction (MI) triggers a dynamic microRNA response with the
potential of yielding therapeutic targets. Objective We aimed to identify novel aberrantly …
potential of yielding therapeutic targets. Objective We aimed to identify novel aberrantly …
Cardiomyocyte‐specific miR‐100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS …
C Smolka, D Schlösser, C Koentges… - The FASEB …, 2021 - Wiley Online Library
MicroRNAs are key regulators of the cardiac response to injury. MiR‐100 has recently been
suggested to be involved in different forms of heart failure, but functional studies are lacking …
suggested to be involved in different forms of heart failure, but functional studies are lacking …
Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent …
RS Nagalingam, NR Sundaresan, M Noor… - Journal of Biological …, 2014 - ASBMB
Understanding the regulation of cardiac fibrosis is critical for controlling adverse cardiac
remodeling during heart failure. Previously we identified miR-378 as a cardiomyocyte …
remodeling during heart failure. Previously we identified miR-378 as a cardiomyocyte …
In vivo inhibition of miR-34a modestly limits cardiac enlargement and fibrosis in a mouse model with established type 1 diabetes-induced cardiomyopathy, but does …
BC Bernardo, GS Yildiz, H Kiriazis, CA Harmawan… - Cells, 2022 - mdpi.com
MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology,
and we previously reported that inhibition of miR-34a in vivo provided protection in a setting …
and we previously reported that inhibition of miR-34a in vivo provided protection in a setting …