The circadian system is an important regulator of immune function. Human inflammatory
lung diseases frequently show time-of-day variation in symptom severity and lung function …

Circadian rhythms are daily cycles in biological function that are ubiquitous in nature.
Understood as a means for organisms to anticipate daily environmental changes, circadian …

Circadian rhythms are known to regulate immune responses in healthy animals, but it is
unclear whether they persist during acute illnesses where clock gene expression is …

The circadian cycle allows organisms to track external time of day and predict/respond to
changes in the external environment. In higher order organisms, circadian rhythmicity is a …

Circadian clocks have evolved to regulate physiologic and behavioral rhythms in
anticipation of changes in the environment. Although the molecular clock is present in innate …

Time of day-dependent variations of immune system parameters are ubiquitous phenomena
in immunology. The circadian clock has been attributed with coordinating these variations …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

Immunity is a high-cost, high-benefit trait that defends against pathogens and noxious stimuli
but whose overactivation can result in immunopathologies and sometimes even death …

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker
cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the …

Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is
essential for fighting infection, a balance of anti-viral defense and host tolerance is …