Bacterial fitness depends on adaptability to changing environments. In rich growth medium,
which is replete with amino acids, Escherichia coli primarily expresses protein synthesis …

A grand challenge of systems biology is to predict the kinetic responses of living systems to
perturbations starting from the underlying molecular interactions. Changes in the nutrient …

Cells usually respond to changing growth conditions with a change in the specific growth
rate (μ) and adjustment of their proteome to adapt and maintain metabolic efficiency …

Recent developments in high-throughput reverse genetics, have revolutionized our ability to
map gene function and interactions,,–. The power of these approaches depends on their …

A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …

Living cells react to changes in growth conditions by re-shaping their proteome. This
accounts for different stress-response strategies, both specific (ie, aimed at increasing the …

Enzyme reprofiling in bacteria during adaptation from one environmental condition to
another may be regulated by both transcription and translation. However, little is known …

Bacterial populations growing in a changing world must adjust their proteome composition
in response to alterations in the environment. Rapid proteome responses to growth medium …

The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically,
recent characterization of the proteome of Escherichia coli found many proteins expressed …

The costs and benefits of protein expression are balanced through evolution. Expression of
un-utilized protein (that have no benefits in the current environment) incurs a quantifiable …