Clozapine is superior to other antipsychotics as a therapy for treatment-resistant
schizophrenia and schizoaffective disorder with increased risk of suicidal behavior. This …

Schizophrenia is a heterogenous and severe neuropsychiatric disorder that affects nearly
1% of the population worldwide. Antipsychotic drugs are the mainstay of treatment, but not …

Consensus of opinion is rare in psychiatry. Even in the field of clinical trials, where
experimentation is tightly controlled and regulatory bodies scrutinize the proof, controversies …

Clozapine was the first true breakthrough in schizophrenia treatment since the discovery of
chlorpromazine in 1950, effectively treating positive, negative, and some cognitive …

Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic
effects are probably mediated by dopaminergic and serotonergic activity. Although it …

Abstract Clozapine [8‐chloro‐11‐(4‐methyl‐1‐piperazinyl)‐3H‐dibenzo (b, e)(1, 4)
diazepinel, or clozaril, is a member of the dibenazepine class of antipsychotic drugs. Initially …

Schizophrenia is a devastating illness that affects up to 1% of the population; it is
characterized by a combination of positive symptoms, negative symptoms, and cognitive …

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Clozapine (CLOZ) is an atypical antipsychotic drug being used with increasing frequency
throughout the world and has recently been commercially marketed in the United States. Its …

Clozapine is often referred to as the gold standard for the treatment of schizophrenia and yet
has also been described as the most underutilized treatment for schizophrenia supported by …