Background Repurposed memantine, mefloquine, and metformin have putative anticancer
activity. The objective of this phase 1 study was to determine the maximum tolerated doses …

Aim This study assesses the impact of six versus 12 cycles of adjuvant Temozolomide (TMZ)
on Overall Survival (OS) in newly diagnosed postoperative patients of Glioblastoma …

Background Chemoradiation, followed by adjuvant temozolomide, is the standard treatment
for newly diagnosed glioblastoma. Adding other active agents may enhance treatment …

Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ)
chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The …

The purpose of this study was to report our experience with concomitant and adjuvant
temozolomide (TMZ) with radiotherapy in patients with newly diagnosed glioblastoma …

Purpose Temozolomide (TMZ), given concurrently with radiotherapy (RT) and as adjuvant
monotherapy afterwards, has led to improved survival in glioblastoma multiforme (GBM) …

External beam radiation therapy (XRT) with concomitant temozolomide and 6 cycles of
adjuvant temozolomide (5/28-day schedule) improves survival in patients with newly …

Purpose Alternative dosing schedules of temozolomide may improve survival in patients
with newly diagnosed glioblastoma (GBM) by increasing the therapeutic index, overcoming …

Purpose Long-term administration of adjuvant temozolomide is common practice in many
institutions, especially when treatment is well tolerated and stable disease is achieved. In …

Materials and methods All patients with GBM managed radically at The Cancer Institute
Radiation Oncology from May 2002 to 2006 were entered into a prospective database …