Signaling pathways function as the information-passing mechanisms of cells. A number of
databases with extensive manual curation represent the current knowledge base for …

Signaling pathways play an important role in the cell's response to its environment.
Signaling pathways are often represented as directed graphs, which are not adequate for …

Signaling pathways describe a group of molecules in a cell that collaborate to control one or
more cell functions, such as cell division or cell death. The pathways communicate by …

Characterizing cellular responses to different extrinsic signals is an active area of research,
and curated pathway databases describe these complex signaling reactions. Here, we …

Background Representing biological networks as graphs is a powerful approach to reveal
underlying patterns, signatures, and critical components from high-throughput biomolecular …

Motivation Molecular interactions have widely been modelled as networks. The local wiring
patterns around molecules in molecular networks are linked with their biological functions …

Background Biological signaling pathways that govern cellular physiology form an intricate
web of tightly regulated interlocking processes. Data on these regulatory networks are …

Intracellular signalling systems are highly complex. This complexity makes handling,
analysis and visualisation of available knowledge a major challenge in current signalling …

Biological signaling networks comprise the chemical processes by which cells detect and
respond to changes in their environment. Such networks have been implicated in the …

Cell signaling pathways interact with one another to form networks in mammalian systems.
Such networks are complex in their organization and exhibit emergent properties such as …