Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection

J Vornhagen, B Armistead… - The Journal of …, 2018 - Am Soc Clin Investig
Thirteen percent of pregnancies result in preterm birth or stillbirth, accounting for fifteen
million preterm births and three and a half million deaths annually. A significant cause of …

A murine model of group B Streptococcus vaginal colonization

KA Patras, KS Doran - JoVE (Journal of Visualized Experiments), 2016 - jove.com
Streptococcus agalactiae (group B Streptococcus, GBS), is a Gram-positive, asymptomatic
colonizer of the human gastrointestinal tract and vaginal tract of 10-30% of adults. In immune …

[HTML][HTML] Bacterial and host determinants of group B streptococcal vaginal colonization and ascending infection in pregnancy

A Brokaw, A Furuta, M Dacanay… - Frontiers in cellular …, 2021 - frontiersin.org
Group B streptococcus (GBS) is a gram-positive bacteria that asymptomatically colonizes the
vaginal tract. However, during pregnancy maternal GBS colonization greatly predisposes …

[HTML][HTML] Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice

NM Gilbert, LR Foster, B Cao, Y Yin… - American journal of …, 2021 - Elsevier
Background Group B Streptococcus is a common vaginal bacterium and the leading cause
of invasive fetoplacental infections. Group B Streptococcus in the vagina can invade through …

Bacterial hyaluronidase promotes ascending GBS infection and preterm birth

J Vornhagen, P Quach, E Boldenow, S Merillat… - MBio, 2016 - Am Soc Microbiol
Preterm birth increases the risk of adverse birth outcomes and is the leading cause of
neonatal mortality. A significant cause of preterm birth is in utero infection with vaginal …

[HTML][HTML] Characterization of host immunity during persistent vaginal colonization by Group B Streptococcus

KA Patras, B Rösler, ML Thoman, KS Doran - Mucosal immunology, 2015 - Elsevier
Abstract Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive
bacterium, which colonizes the vaginal tract in 10–30% of women. Colonization is transient …

Group B Streptococcus β-hemolysin/Cytolysin Breaches Maternal-Fetal Barriers to Cause Preterm Birth and Intrauterine Fetal Demise in Vivo

TM Randis, SE Gelber, TA Hooven… - The Journal of …, 2014 - academic.oup.com
Background. Maternal vaginal colonization with Streptococcus agalactiae (Group B
Streptococcus [GBS]) is a precursor to chorioamnionitis, fetal infection, and neonatal sepsis …

The double life of group B Streptococcus: asymptomatic colonizer and potent pathogen

B Armistead, E Oler, KA Waldorf, L Rajagopal - Journal of molecular biology, 2019 - Elsevier
Group B streptococcus (GBS) is a β-hemolytic gram-positive bacterium that colonizes the
lower genital tract of approximately 18% of women globally as an asymptomatic member of …

Role of MUC5B during group B streptococcal vaginal colonization

LR Burcham, JR Bath, CA Werlang, LM Lyon, N Liu… - Mbio, 2022 - Am Soc Microbiol
The female reproductive tract (FRT) is a complex environment, rich in mucin glycoproteins
that form a dense network on the surface of the underlying epithelia. Group B Streptococcus …

[HTML][HTML] Group B streptococcal maternal colonization and neonatal disease: molecular mechanisms and preventative approaches

KA Patras, V Nizet - Frontiers in pediatrics, 2018 - frontiersin.org
Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a
significant percentage of healthy women, with potential for ascending intrauterine infection …