A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis

C Li, X Wu, H Zhang, G Yang, M Hao, S Sheng… - International journal of …, 2015 - Elsevier
Hepatocellular carcinoma (HCC) is a highly metastatic cancer. Huaier polysaccharide (TP-1)
is a naturally occurring bioactive macromolecule, found in Huaier fungus and has been …

A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway

C Li, X Wu, H Zhang, G Yang, M Hao, S Sheng, Y Sun… - Tumor Biology, 2015 - Springer
TP-1 is a polysaccharide from one famous fungus Huaier. Treatment with TP-1 significantly
inhibited the cell growth, adhesion, migration, and motility of SMMC-7721 cells in a dose …

A Huaier polysaccharide inhibits hepatocellular carcinoma growth and metastasis

C Li, X Wu, H Zhang, G Yang, M Hao, S Sheng, Y Sun… - Tumor Biology, 2015 - Springer
This study was carried out to evaluate the effects of a Huaier polysaccharide (TP-1) on the
tumor growth and immune function in hepatocellular carcinoma (HCC) H22-based mouse in …

A polysaccharide from mushroom Huaier retards human hepatocellular carcinoma growth, angiogenesis, and metastasis in nude mice

Y Zou, H Xiong, H Xiong, T Lu, F Zhu, Z Luo, X Yuan… - Tumor Biology, 2015 - Springer
Mushroom Huaier has become a focus of interest in the treatment of hepatocellular
carcinoma (HCC). Presently, we isolated and purified one polysaccharide from this …

Dandelion polysaccharide exerts anti-angiogenesis effect on hepatocellular carcinoma by regulating VEGF/HIF-1α expression

F Ren, K Wu, Y Yang, Y Yang, Y Wang… - Frontiers in …, 2020 - frontiersin.org
Recent studies have revealed that natural plants-derived polysaccharides exhibit potent anti-
tumor activity. Our earlier studies suggest that dandelion polysaccharide (DP) inhibits …

[HTML][HTML] Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK

H Bao, P Liu, K Jiang, X Zhang, L Xie… - Oncology …, 2016 - spandidos-publications.com
The underlying mechanism of the antitumor activity of Huaier polysaccharide (HP) remains
to be explored. The present study aimed to investigate the inhibitory effect of HP on …

A polysaccharide from Hedyotis diffusa interrupts metastatic potential of lung adenocarcinoma A549 cells by inhibiting EMT via EGFR/Akt/ERK signaling pathways

L Lin, K Cheng, Z He, Q Lin, Y Huang, C Chen… - International journal of …, 2019 - Elsevier
In this study we investigated the potential effects of a polysaccharide (HDP) from Hedyotis
diffusa on the metastasis in human lung adenocarcinoma A549 cells. HDP (25, 50 and 100 …

Acidic mucopolysaccharide from Holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro

W Zhang, Y Lu, B Xu, J Wu, L Zhang, M Gao… - Cancer Biology & …, 2009 - Taylor & Francis
Acidic mucopolysaccharide from Holothuria Leucospilota( HS) may affect some steps in
metastasis cascade. In vitro, HS inhibited the growth of B16F10 cells and proliferation of …

A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein

Z Luo, X Hu, H Xiong, H Qiu, X Yuan, F Zhu… - Carbohydrate …, 2016 - Elsevier
In this study, one homogeneous polysaccharide (SP1), with a molecular weight of 56 kDa,
was isolated from the Huaier fruiting bodies. It had a backbone consisting of 1, 4-linked-β-d …

Asparagus Polysaccharide Suppresses the Migration, Invasion, and Angiogenesis of Hepatocellular Carcinoma Cells Partly by Targeting the HIF‐1α/VEGF Signalling …

W Cheng, Z Cheng, D Xing… - … and Alternative Medicine, 2019 - Wiley Online Library
Hypoxia‐inducible factor‐1α (HIF‐1α) plays a key role by triggering the transcriptional
activation of a number of genes involved in migration, invasion, and angiogenesis in …