The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of IFN-
γ immunity. Affected patients are highly and selectively susceptible to weakly virulent …

INTRODUCTION Interindividual clinical variability is vast in humans infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to …

Background We previously reported that impaired type I IFN activity, due to inborn errors of
TLR3-and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of IFN‐
γ immunity. Since 1996, disease‐causing mutations have been found in 11 genes, which …

Mendelian Susceptibility to Mycobacterial diseases (MSMD) are a group of innate immune
defects with more than 17 genes and 32 clinical phenotypes identified. Defects in the IFN-γ …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …

INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …

Primary immunodeficiencies (PIDs) were long thought to be exclusively recessive traits—
autosomal recessive (AR) in most cases, with a few X-linked recessive (XR) diseases. In …