The priming of natural killer (NK) cells by type I interferon (IFN) is necessary for protection
against primary and secondary viral infections. However, the pathway by which type I IFN …

Type I interferon (IFN) is crucial in host antiviral defense. Previous studies have described
the pleiotropic role of type I IFNs on innate and adaptive immune cells during viral infection …

Despite development of new antiviral drugs, viral infections are still a major health problem.
The most potent antiviral defense mechanism is the innate production of type I interferon …

NK cells are a key antiviral component of the innate immune response to HSV-2, particularly
through their production of IFN-γ. It is still commonly thought that type I IFN activates NK cell …

Direct type I interferon (IFN) signaling on T cells is necessary for the proper expansion,
differentiation, and survival of responding T cells following infection with viruses prominently …

Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon
(IFN-γ) in part because they basally express high levels of the signal transducer and …

Type I interferons (IFN) are unique cytokines transcribed from intronless genes. They have
been extensively studied because of their anti-viral functions. The anti-viral effects of type I …

The innate immune response mediated by cells such as natural killer (NK) cells is critical for
the rapid containment of virus replication and spread during acute infection. Here, we show …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

Abstract The role of Natural Killer cells in host defense against infections as well as in
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …