Kaempferol and fisetin-related signaling pathways induce apoptosis in head and neck cancer cells

R Kubina, K Krzykawski, A Dziedzic, A Kabała-Dzik - Cells, 2023 - mdpi.com
Despite the relative effectiveness of standard cancer treatment strategies, head and neck
cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While …

Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells

HS Lee, HJ Cho, R Yu, KW Lee, HS Chun… - International journal of …, 2014 - mdpi.com
We previously noted that kaempferol, a flavonol present in vegetables and fruits, reduced
cell cycle progression of HT-29 cells. To examine whether kaempferol induces apoptosis of …

Anticancer potential of selected flavonols: Fisetin, kaempferol, and quercetin on head and neck cancers

R Kubina, M Iriti, A Kabała-Dzik - Nutrients, 2021 - mdpi.com
Flavonols are ones of the most common phytochemicals found in diets rich in fruit and
vegetables. Research suggests that molecular functions of flavonoids may bring a number of …

Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways

E Kashafi, M Moradzadeh, A Mohamadkhani… - Biomedicine & …, 2017 - Elsevier
Cervical cancer is one of the most frequent cancers in women worldwide. Defects in the
apoptotic pathways are responsible for both the disease pathogenesis and its therapy …

Kaempferol regresses carcinogenesis through a molecular cross talk involved in proliferation, apoptosis and inflammation on human cervical cancer cells, HeLa

N Afroze, S Pramodh, AG Almutary, TA Rizvi, N Rais… - Applied Sciences, 2022 - mdpi.com
Kaempferol, a flavonoid, contains a plethora of therapeutic properties and has demonstrated
its efficacy against cancer. This study aims to unravel the molecular targets that are being …

Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mTOR and ERK1/2 signaling pathways

XJ Zhang, SS Jia - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Targeting cancer cells is crucial for improving the efficiency of laryngeal cancer treatment.
However, the signaling pathway and therapeutic strategy, related to the tumor, still need …

Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes

HWC Leung, CJ Lin, MJ Hour, WH Yang… - Food and Chemical …, 2007 - Elsevier
Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone) is one of the most commonly found dietary
flavonols. The biological and pharmacological effects of kaempferol may depend upon its …

Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated …

W Li, B Du, T Wang, S Wang, J Zhang - Chemico-Biological Interactions, 2009 - Elsevier
Dietary flavonols have been found to possess preventive and therapeutic potential against
several kinds of cancers. This study is conducted to investigate the anti-proliferation effects …

Anti-cancer effect and underlying mechanism (s) of kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models

SH Kim, KC Choi - Toxicological research, 2013 - Springer
Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long
times, phytoestrogens have been used for therapeutic treatments against human diseases …

The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells

AK Shendge, D Chaudhuri, N Mandal - Molecular Biology Reports, 2021 - Springer
Brain and CNS-related cancers are rare; however, 0.3 million incidences and 0.24 million
deaths in 2018 demonstrates the unrelenting associated dangers. Glioblastoma is a brain …