[HTML][HTML] A specific and portable gene expression program underlies antigen archiving by lymphatic endothelial cells

RM Sheridan, TA Doan, C Lucas, TS Forward… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Antigens from protein subunit vaccination traffic from the tissue to the draining lymph node,
either passively via the lymph or carried by dendritic cells at the local injection site. Lymph …

Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction

RM Kedl, RS Lindsay, JM Finlon, ED Lucas… - Nature …, 2017 - nature.com
Antigens derived from viral infection or vaccination can persist within a host for many weeks
after resolution of the infection or vaccine responses. We previously identified lymphatic …

Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection

TA Doan, TS Forward, JB Schafer, ED Lucas, I Fleming… - npj Vaccines, 2024 - nature.com
Antigens from viruses or immunizations can persist or are archived in lymph node stromal
cells such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here …

[HTML][HTML] Vaccine-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection

B Tamburini, T Doan, T Forward, E Lucas… - Research …, 2023 - ncbi.nlm.nih.gov
Viral and vaccine antigens persist or are archived in lymph node stromal cells (LNSC) such
as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here, we find that …

Comparative transcriptomic analysis identifies a range of immunologically related functional elaborations of lymph node associated lymphatic and blood endothelial …

SJ Berendam, AF Koeppel, NR Godfrey… - Frontiers in …, 2019 - frontiersin.org
Lymphatic and blood vessels are formed by specialized lymphatic endothelial cells (LEC)
and blood endothelial cells (BEC), respectively. These endothelial populations not only form …

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

BA Tamburini, MA Burchill, RM Kedl - Nature communications, 2014 - nature.com
Antigen derived from viral infections with influenza and vesicular stomatitis virus can persist
after resolution of infection. Here we show that antigen can similarly persist for weeks …

[HTML][HTML] Lymphatic vessel transit seeds precursors to cytotoxic resident memory T cells in skin draining lymph nodes

TA Heim, AC Schultz, I Delclaux, V Cristaldi… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Resident memory T cells (T RM) provide rapid, localized protection in peripheral tissues to
pathogens and cancer. While T RM are also found in lymph nodes (LN), how they develop …

Antigen archiving by lymph node stroma: a novel function for the lymphatic endothelium

RM Kedl, BA Tamburini - European journal of immunology, 2015 - Wiley Online Library
Secondary lymphoid stroma performs far more functions than simple structural support for
lymphoid tissues, providing a host of soluble and membrane‐bound cues to trafficking …

Lymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodes

TA Heim, AC Schultz, I Delclaux, V Cristaldi… - Science …, 2024 - science.org
Lymphatic transport shapes the homeostatic immune repertoire of lymph nodes (LNs). LN-
resident memory T cells (TRMs) play an important role in site-specific immune memory, yet …

[HTML][HTML] The antigen processing and presentation machinery in lymphatic endothelial cells

L Santambrogio, SJ Berendam… - Frontiers in …, 2019 - frontiersin.org
Until a few years ago, lymphatic vessels and lymphatic endothelial cells (LEC) were viewed
as part of a passive conduit for lymph and immune cells to reach lymph nodes (LN) …