Experimental models to study end-organ morbidity in sleep apnea: lessons learned and future directions

R Farré, I Almendros, MÁ Martínez-García… - International Journal of …, 2022 - mdpi.com
Sleep apnea (SA) is a very prevalent sleep breathing disorder mainly characterized by
intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation …

Human experimental models: seeking to enhance multiscale research in sleep apnoea

R Farré, D Gozal, I Almendros - European Respiratory Journal, 2021 - Eur Respiratory Soc
Human experimental models: seeking to enhance multiscale research in sleep apnoea |
European Respiratory Society Skip to main content Main menu Home Current issue ERJ Early …

Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding of the human disease

M Dematteis, D Godin-Ribuot, C Arnaud, C Ribuot… - ILAR …, 2009 - academic.oup.com
Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea
syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep …

[HTML][HTML] Intermittent hypoxia severity in animal models of sleep apnea

R Farré, JM Montserrat, D Gozal, I Almendros… - Frontiers in …, 2018 - frontiersin.org
Obstructive sleep apnea (OSA) is a very prevalent breathing disorder (Peppard et al., 2013;
Heinzer et al., 2015) characterized by recurrent obstructions of the upper airway during …

New frontiers in obstructive sleep apnoea

NT Ayas, AAJ Hirsch, I Laher, TD Bradley… - Clinical …, 2014 - portlandpress.com
OSA (obstructive sleep apnoea), the most common respiratory disorder of sleep, is caused
by the loss of upper airway dilating muscle activity during sleep superimposed on a narrow …

Sleep apnea research in animals. Past, present, and future

S Chopra, VY Polotsky, JC Jun - American journal of respiratory cell …, 2016 - atsjournals.org
Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of
the upper airway during sleep. Animal models have been pivotal to the understanding of …

Morbidity due to obstructive sleep apnea: insights from animal models

R Farré, JM Montserrat, D Navajas - Current opinion in pulmonary …, 2008 - journals.lww.com
The simple experimental models used to investigate OSA morbidity are useful for
investigating isolated mechanisms. However, more complex and realistic models …

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer

I Hunyor, KM Cook - American Journal of Physiology …, 2018 - journals.physiology.org
Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A
key modulator of this disease is nocturnal intermittent hypoxia. There is striking …

Advanced concepts in the pathophysiology of obstructive sleep apnea

DP White - Sleep-Related Breathing Disorders, 2017 - karger.com
The primary pathological event in the disorder obstructive sleep apnea (OSA) is the partial
or complete closure of the pharyngeal airway during sleep in an individual with a widely …

Biological plausibility linking sleep apnoea and metabolic dysfunction

A Gileles-Hillel, L Kheirandish-Gozal… - Nature Reviews …, 2016 - nature.com
Obstructive sleep apnoea (OSA) is a very common disorder that affects 10–25% of the
general population. In the past two decades, OSA has emerged as a cardiometabolic risk …