Episodic memories initially require rapid synaptic plasticity within the hippocampus for their
formation and are gradually consolidated in neocortical networks for permanent storage …

Memory resides in engram cells distributed across the brain. However, the site-specific
substrate within these engram cells remains theoretical, even though it is generally accepted …

As basic units of neural networks, ensembles of synapses underlie cognitive functions such
as learning and memory. These synaptic engrams show elevated synaptic density among …

INTRODUCTION Associative learning is essential for survival, and the mammalian
hippocampal neurocircuitry has been shown to play a central role in the formation of specific …

Episodic memory requires associations of temporally discontiguous events. In the entorhinal-
hippocampal network, temporal associations are driven by a direct pathway from layer III of …

Memories are integrated into interconnected networks; nevertheless, each memory has its
own identity. How the brain defines specific memory identity out of intermingled memories …

Associating temporally discontinuous elements is crucial for the formation of episodic and
working memories that depend on the hippocampal-entorhinal network. However, the neural …

The hippocampus is thought to initiate systems-wide mnemonic processes through the
reactivation of previously acquired spatial and episodic memory traces, which can recruit the …

BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Increased fear memory generalization is associated with posttraumatic stress disorder, but
the circuit mechanisms that regulate memory specificity remain unclear. Here, we define a …