Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized
by an increase in differentiation of fibroblasts to myofibroblasts and excessive accumulation …

Pulmonary fibrosis is a chronic, progressive, incurable interstitial lung disease with high
mortality after diagnosis and remains a global public health problem. Despite advances and …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder in which excessive
deposition of extracellular matrix leads to irreversible scarring of interstitial lung tissue. The …

Epithelial-mesenchymal transition (EMT) is a phenotype conversion that plays a critical role
in the development of pulmonary fibrosis (PF). It is known that snail could regulate the …

Aims: Oxidants have been implicated in the pathophysiology of idiopathic pulmonary fibrosis
(IPF), especially in myofibroblastic differentiation. We aimed at testing the hypothesis that …

The molecular mechanisms of pulmonary fibrosis are poorly understood, although reactive
oxygen species are thought to have an important role. NRF2 is a transcription factor that …

Background Pulmonary fibrosis is a progressive and lethal disorder. Although the precise
mechanisms of pulmonary fibrosis are not fully understood, oxidant/antioxidant and Th1/Th2 …

The transcription factor, nuclear factor (NF), erythroid-derived 2–related factor 2 (NRF2), was
discovered nearly 2 decades ago. Since then, over 4,000 papers have been published on …

Transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of
antioxidant response element-(ARE-) driven cytoprotective protein expression. The …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …