Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

[HTML][HTML] The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?

E Razani, A Pourbagheri-Sigaroodi… - Cell Stress and …, 2021 - Elsevier
Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

[HTML][HTML] PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

[HTML][HTML] Implications of PI3K/AKT/PTEN signaling on superoxide dismutases expression and in the pathogenesis of Alzheimer's disease

S Matsuda, Y Nakagawa, A Tsuji, Y Kitagishi… - Diseases, 2018 - mdpi.com
Alzheimer's disease is a neurodegenerative sickness, where the speed of personal disease
progression differs prominently due to genetic and environmental factors such as life style …

[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

A Goyal, A Agrawal, A Verma, N Dubey - Experimental and Molecular …, 2023 - Elsevier
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …

The role of PI3K/Akt and ERK in neurodegenerative disorders

SN Rai, H Dilnashin, H Birla, SS Singh, W Zahra… - Neurotoxicity …, 2019 - Springer
Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …

[HTML][HTML] p38 MAPK and PI3K/AKT signalling cascades inParkinson's disease

SK Jha, NK Jha, R Kar, RK Ambasta… - International journal of …, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

[HTML][HTML] Altered insulin signaling in Alzheimer's disease brain–special emphasis on PI3K-Akt pathway

S Gabbouj, S Ryhänen, M Marttinen… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective …

[HTML][HTML] Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease

Y Kitagishi, A Nakanishi, Y Ogura… - Alzheimer's research & …, 2014 - Springer
Alzheimer's disease (AD) is characterized by the formation of senile plaques and
neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that …

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

RJ Griffin, A Moloney, M Kelliher… - Journal of …, 2005 - Wiley Online Library
Studies suggest that activation of phosphoinositide 3‐kinase‐Akt may protect against
neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of …