Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …
and mortality in aged population. Several transcription molecules, pathways, and molecular …
[HTML][HTML] The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?
E Razani, A Pourbagheri-Sigaroodi… - Cell Stress and …, 2021 - Elsevier
Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …
[HTML][HTML] PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease
HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …
diseases that increased with aging. With the emergence of aging population, the health …
[HTML][HTML] Implications of PI3K/AKT/PTEN signaling on superoxide dismutases expression and in the pathogenesis of Alzheimer's disease
S Matsuda, Y Nakagawa, A Tsuji, Y Kitagishi… - Diseases, 2018 - mdpi.com
Alzheimer's disease is a neurodegenerative sickness, where the speed of personal disease
progression differs prominently due to genetic and environmental factors such as life style …
progression differs prominently due to genetic and environmental factors such as life style …
[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
The role of PI3K/Akt and ERK in neurodegenerative disorders
Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
[HTML][HTML] p38 MAPK and PI3K/AKT signalling cascades inParkinson's disease
SK Jha, NK Jha, R Kar, RK Ambasta… - International journal of …, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …
[HTML][HTML] Altered insulin signaling in Alzheimer's disease brain–special emphasis on PI3K-Akt pathway
S Gabbouj, S Ryhänen, M Marttinen… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective …
prevalence in aging populations. T2D, characterized by insulin resistance and defective …
[HTML][HTML] Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease
Y Kitagishi, A Nakanishi, Y Ogura… - Alzheimer's research & …, 2014 - Springer
Alzheimer's disease (AD) is characterized by the formation of senile plaques and
neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that …
neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that …
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
RJ Griffin, A Moloney, M Kelliher… - Journal of …, 2005 - Wiley Online Library
Studies suggest that activation of phosphoinositide 3‐kinase‐Akt may protect against
neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of …
neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of …