In microorganisms, different from primary metabolism for cellular growth, secondary
metabolism is for ecological interactions and stress responses and an important source of …

Microbiological studies are increasingly relying on in silico methods to perform exploration
and rapid analysis of genomic data, and functional genomics studies are supplemented by …

Rational engineering of metabolism is important for bio-production using microorganisms.
Metabolic design based on in silico simulations and experimental validation of the metabolic …

Background Modeling of microbial metabolism is a topic of growing importance in
biotechnology. Mathematical modeling helps provide a mechanistic understanding for the …

The exploitation of microbial manufacture process (MMP) in industrial biotechnology
requires a comprehensive understanding and an efficient modification of microorganism …

Metabolic engineering of various industrial microorganisms to produce chemicals, fuels, and
drugs has raised interest since it is environmentally friendly, sustainable, and independent …

Constraint-based metabolic modeling such as flux balance analysis (FBA) has been widely
used to simulate cell metabolism. Thanks to its simplicity and flexibility, numerous algorithms …

Flux balance analysis (FBA) is an important method for calculating optimal pathways to
produce industrially important chemicals in genome-scale metabolic models (GEMs) …

Background Flux analyses, including flux balance analysis (FBA) and 13 C-metabolic flux
analysis (13 C-MFA), offer direct insights into cell metabolism, and have been widely used to …

Most natural microbial systems have evolved to function in environments with temporal and
spatial variations. A major limitation to understanding such complex systems is the lack of …