The kynurenine pathway is important in cellular energy generation and limiting cellular
ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD+ …

Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

The tryptophan and kynurenine pathway is well-known to play an important role in nervous,
endocrine, and immune systems, as well as in the development of inflammatory diseases. It …

The kynurenine pathway (KP) of L-tryptophan metabolism produces several neuroactive
metabolites with an amino acid structure. These metabolites may play an important role in …

The intestine and the gut-associated limphoid tissue constitute the largest immunity organ of
the human body. Among several possible tryptophan metabolism routes, the kynurenine …

Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …

BACKGROUND The essential amino acid tryptophan is a substrate for the generation of
several bioactive compounds with important physiological roles. Only a small fraction of …

The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

It has become increasingly clear that the gut microbiota influences not only gastrointestinal
physiology but also central nervous system (CNS) function by modulating signalling …