In this work, we synthesized a series of indole derivatives to cope with the current increasing
fungal infections caused by drug-resistant Candida albicans. All compounds were evaluated …

With the widespread use of azole antifungals in the clinic, the drug resistance has been
emerging continuously. In this work, we have designed and prepared a series of novel …

Candida albicans is the most common fungal pathogen associated with human opportunistic
infections. Invasive infections caused by C. albicans are becoming increasingly serious …

In present work, a series of quinoline derivatives linked to chalcone moiety have been
prepared, and their in vitro and in vivo antifungal activities against C. albicans have been …

The increasing resistance of Candida albicans against the currently available antifungal
drugs has exerted enormous damage to human health. To develop novel and efficient …

With the increasing of Candida albicans infections year by year, and the widespread use of
azole drugs, especially fluconazole has led to the emergence of drug resistance. Therefore …

A compound containing an imidazole moiety and a 2, 4-dienone motif with significant activity
toward several fungi was discovered in a screen for new antifungal compounds. Then, a …

Background Candida albicans (C. albicans) is an opportunistic pathogen that can cause
superficial and life-threatening systemic infections in immunocompromised patients …

In this study, we designed and prepared a series of new azole derivatives by recombination
of fluconazole (FLC) and ketoconazole units, and in vitro antifungal activities against …

With the widespread clinical use of FLC, the FLC-resistant C. albicans greatly increases the
difficulty of treatment, and drug combination becomes an important method to treat C …