The skin locally synthesizes significant amounts of sexual hormones with intracrine or
paracrine actions. The local level of each sexual steroid depends upon the expression of …

Androgens affect several functions of the human skin, such as sebaceous gland growth and
differentiation, hair growth, epidermal barrier homeostasis and wound healing. Their effects …

Although the human sebaceous gland can synthesize cholesterol from acetate and can
further metabolize steroids such as dehydroepiandrosterone into potent androgens, the de …

The skin, especially the pilosebaceous unit composed of sebaceous glands and hair
follicles, can synthesize androgens de novo from cholesterol or by locally converting …

The mRNA expression patterns of the androgen receptor and the androgen metabolizing
enzymes 3β-hydroxysteroid dehydrogenase/Δ 5-4-isomerase, 17β-hydroxysteroid …

The skin, the largest organ in the human body, is composed of a series of androgen-
sensitive components that all express the steroidogenic enzymes required to transform …

There is still extensive disparity in our understanding of how estrogens exert their actions,
particularly in non‐reproductive tissues such as the skin. Although it has been recognized …

Sex steroid hormones are involved in regulation of skin development and functions as well
as in some skin pathological events. To determine the sites of action of estrogens …

The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various
hormones from their precursors, as well as of synthesizing de novo a broad palette of sex …

The skin is an endocrine organ with the expression of metabolizing enzymes and hormone
receptors for diverse hormones. The sebaceous gland is the main site of hormone …